Results 231 to 240 of about 16,475 (291)

Machine learning insights into nurse retention through job satisfaction and financial incentives. [PDF]

Front Psychol
Sarıdoğan AA, Küçükgergerli N, Ertürk M, Emeç M, Yaman A.   +4 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Protecting providers: A qualitative study of Veterans Health Administration mental health providers' perspectives on leadership and burnout. [PDF]

Psychol Serv
Ortolan V, Abraham KM, Harrod M, Takamine L, Burgess J, Sripada RK, Grau PP, Zivin K.   +7 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

National Public Health Institutes Organizational Strengthening Module Framework: Applying Organizational Development Principles. [PDF]

Ann Glob Health
Hansoti B, Stodola C, Ridhi S, Adhikari B, Engineer C, Bratton S, Carnevale C, Gilayeneh JSM, Chilengi R, Bennett S.   +9 more
europepmc   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Understanding error culture in veterinary medicine: a survey among veterinarians across German-speaking countries. [PDF]

Front Vet Sci
Montag CM, Kleinsorgen C, Rösch-Rodax D, Volk HA, Busse C.   +4 more
europepmc   +1 more source

Helping hands, flourishing hearts: A meta-analytic study of organizational citizenship behaviors and subjective well-being. [PDF]

Appl Psychol Health Well Being
Wiese CW, Scotney VS, Hou DX, Tay L.
europepmc   +1 more source

A multi-method analysis of employee-driven green service innovation in hotels based on the ability-motivation-opportunity framework. [PDF]

Sci Rep
Li Y, Li T, Ling Y, Feng X, Wang H, Liao C.   +5 more
europepmc   +1 more source