Results 51 to 60 of about 15,174 (248)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Global greenness in relation to reducing the burden of cardiovascular diseases: ischemic heart disease and stroke

Environmental Research Letters, 2020
This ecological study aimed to identify the association between greenness and cardiovascular diseases in terms of ischemic heart disease (IHD) and stroke in 183 countries worldwide. The country-level disability-adjusted life year (DALY) database provided
Aji Kusumaning Asri, Chia-Pin Yu, Wen-Chi Pan, Yue Leon Guo, Huey-Jen Su, Shih-Chun Candice Lung, Chih-Da Wu, John D Spengler   +7 more
doaj   +1 more source

Association Between Long‐Term Exposure to Fine Particulate Matter Constituents and Progression of Cerebral Blood Flow Velocity in Beijing: Modifying Effect of Greenness

GeoHealth, 2023
Few studies have explored the effects of fine particulate matter (PM2.5) and its constituents on the progression of cerebral blood flow velocity (BFV) and the potential modifying role of greenness.
Zongkai Xu, Ze Han, Jinqi Wang, Rui Jin, Zhiwei Li, Zhiyuan Wu, Zemeng Zhao, Shiyun Lv, Xiaoyu Zhao, Yueruijing Liu, Xiuhua Guo, Lixin Tao   +11 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The grey-green divide: multi-temporal analysis of greenness across 10,000 urban centres derived from the Global Human Settlement Layer (GHSL)

International Journal of Digital Earth, 2020
The presence of green spaces within city centres has been recognized as a valuable component of the city landscape. Vegetation provides a variety of benefits including energy saving, improved air quality, reduced noise pollution, decreased ambient ...
Christina Corbane, Pesaresi Martino, Politis Panagiotis, Florczyk J. Aneta, Melchiorri Michele, Freire Sergio, Schiavina Marcello, Ehrlich Daniele, Naumann Gustavo, Kemper Thomas   +9 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Elevation-Dependent Contribution of the Response and Sensitivity of Vegetation Greenness to Hydrothermal Conditions on the Grasslands of Tibet Plateau from 2000 to 2021

Remote Sensing
The interrelation between grassland vegetation greenness and hydrothermal conditions on the Tibetan Plateau demonstrates a significant correlation. However, understanding the spatial patterns and the degree of this correlation, especially in relation to ...
Yatang Wu, Changliang Shao, Jing Zhang, Yiliang Liu, Han Li, Leichao Ma, Ming Li, Beibei Shen, Lulu Hou, Shiyang Chen, Dawei Xu, Xiaoping Xin, Xiaoni Liu   +12 more
doaj   +1 more source

Green, Green Destiny

The Iowa Review, 1988
"THOSE BAPTISTS will plop a church down anywhere. All those evan gels are just the same. Driving home today I saw where they converted the old drawbridge tollbooth, converted it right into a sinners do-drop in. I would not be the least bit surprised or astonished to see some small new meeting hall cropped up anywhere.
openaire   +1 more source