Results 71 to 80 of about 1,410,389 (331)

Hippocampal Remapping and Its Entorhinal Origin

Frontiers in Behavioral Neuroscience, 2018
The activity of hippocampal cell ensembles is an accurate predictor of the position of an animal in its surrounding space. One key property of hippocampal cell ensembles is their ability to change in response to alterations in the surrounding environment,
Patrick Latuske, Olga Kornienko, Laura Kohler, Kevin Allen   +3 more
doaj   +1 more source

Solar cell grid patterns [PDF]

, 1976
A grid pattern is described for a solar cell of the type which includes a semiconductive layer doped to a first polarity and a top counter-doped layer.
Berman, P. A., Yasui, R. K.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Grid cells: the missing link in understanding Parkinson’s disease?

Frontiers in Neuroscience
The mechanisms underlying Parkinson’s disease (PD) are complex and not fully understood, and the box-and-arrow model among other current models present significant challenges. This paper explores the potential role of the allocentric brain and especially
Alexander Reinshagen
doaj   +1 more source

Differences in Visual-Spatial Input May Underlie Different Compression Properties of Firing Fields for Grid Cell Modules in Medial Entorhinal Cortex. [PDF]

PLoS Computational Biology, 2015
Firing fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers.
Florian Raudies, Michael E Hasselmo
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Modeling grid fields instead of modeling grid cells [PDF]

, 2018
A neuron’s firing correlates are defined as the features of the external world to which its activity is correlated. In many parts of the brain, neurons have quite simple such firing correlates. A striking example are grid cells in the rodent medial entorhinal cortex: their activity correlates with the animal’s position in space, defining ‘grid fields ...
Sophie Rosay, Simon Weber 0004, Marcello Mulas   +2 more
openaire   +1 more source

Segregation of cortical head direction cell assemblies on alternating theta cycles [PDF]

, 2013
High-level cortical systems for spatial navigation, including entorhinal grid cells, critically depend on input from the head direction system. We examined spiking rhythms and modes of synchrony between neurons participating in head direction networks ...
Bogaard, Andrew R., Brandon, Mark P., Hasselmo, Michael E., Schultheiss, Nathan W.   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Spatial cell firing during virtual navigation of open arenas by head-restrained mice

eLife, 2018
We present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, compatible with multi-photon imaging. This system allows expression of the spatial navigation and neuronal firing patterns characteristic of real open ...
Guifen Chen, John Andrew King, Yi Lu, Francesca Cacucci, Neil Burgess   +4 more
doaj   +1 more source