Results 1 to 10 of about 9,473,872 (308)
Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease. [PDF]
Neuron, 2020 Jun H +5 more
europepmc +2 more sources
Scientific Reports, 2021 iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed
Xuyen T. Dinh +7 more
doaj +1 more source
eLife, 2023 The hippocampus executes crucial functions from declarative memory to adaptive behaviors associated with cognition and emotion. However, the mechanisms of how morphogenesis and functions along the hippocampal dorsoventral axis are differentiated and ...
Xiong Yang +6 more
doaj +1 more source
Molecular Metabolism, 2020 Objective: As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell differentiation enough to account for the altered function.
Aref G. Ebrahimi +5 more
doaj +1 more source
Role of Akt/Protein Kinase B in Cancer Metastasis
Biomedicines, 2023 Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer-related mortalities result from metastatic disease that is resistant to current therapies.
Mohammad Islam, Sarah Jones, Ian Ellis
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A Brain-Inspired Model of Hippocampal Spatial Cognition Based on a Memory-Replay Mechanism
Brain Sciences, 2022 Since the hippocampus plays an important role in memory and spatial cognition, the study of spatial computation models inspired by the hippocampus has attracted much attention.
Runyu Xu, Xiaogang Ruan, Jing Huang
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Frontiers in Systems Neuroscience, 2021 This article describes a neural model of the anatomy, neurophysiology, and functions of intrinsic and extrinsic theta rhythms in the brains of multiple species.
Stephen Grossberg
doaj +1 more source
Cell Reports, 2013 H2O2 can cause oxidative damage associated with age-related diseases such as diabetes and cancer but is also used to initiate diverse responses, including increased antioxidant gene expression.
Jonathon D. Brown +5 more
doaj +1 more source
Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons
Nature Communications, 2016 Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion ...
Hannah Alfonsa +3 more
doaj +1 more source
Engineered kinesin motor proteins amenable to small-molecule inhibition
Nature Communications, 2016 The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable ...
Martin F. Engelke +10 more
doaj +1 more source