Results 1 to 10 of about 987,131 (263)

Neuromorphic Place Cells

open access: yesCoRR, 2023
A neuromorphic SLAM system shows potential for more efficient implementation than its traditional counterpart. We demonstrate a mixed-mode implementation for spatial encoding neurons including theta cells, vector cells, and place cells. Together, they form a biologically plausible network that could reproduce the localization functionality of place ...
Zhaoqi Chen, Ralph Etienne-Cummings
openaire   +2 more sources

Place cells and place navigation [PDF]

open access: yesProceedings of the National Academy of Sciences, 1997
The assumption that hippocampal place cells (PCs) form the neural substrate of cognitive maps can be experimentally tested by comparing the effect of experimental interventions on PC activity and place navigation. Conditions that interfere with place navigation (darkness, cholinergic blockade) but leave PC activity unaffected ...
J, Bures   +3 more
openaire   +2 more sources

Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells

open access: yesScientific Reports, 2021
iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed
Xuyen T. Dinh   +7 more
doaj   +1 more source

Place Cells, Grid Cells, and Memory [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2015
The hippocampal system is critical for storage and retrieval of declarative memories, including memories for locations and events that take place at those locations. Spatial memories place high demands on capacity. Memories must be distinct to be recalled without interference and encoding must be fast.
Moser, May-Britt   +2 more
openaire   +3 more sources

The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes

open access: yeseLife, 2023
The hippocampus executes crucial functions from declarative memory to adaptive behaviors associated with cognition and emotion. However, the mechanisms of how morphogenesis and functions along the hippocampal dorsoventral axis are differentiated and ...
Xiong Yang   +6 more
doaj   +1 more source

Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

open access: yesMolecular Metabolism, 2020
Objective: As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell differentiation enough to account for the altered function.
Aref G. Ebrahimi   +5 more
doaj   +1 more source

Role of Akt/Protein Kinase B in Cancer Metastasis

open access: yesBiomedicines, 2023
Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer-related mortalities result from metastatic disease that is resistant to current therapies.
Mohammad Islam, Sarah Jones, Ian Ellis
doaj   +1 more source

A Brain-Inspired Model of Hippocampal Spatial Cognition Based on a Memory-Replay Mechanism

open access: yesBrain Sciences, 2022
Since the hippocampus plays an important role in memory and spatial cognition, the study of spatial computation models inspired by the hippocampus has attracted much attention.
Runyu Xu, Xiaogang Ruan, Jing Huang
doaj   +1 more source

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