Results 61 to 70 of about 818,302 (255)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Probable nature of higher-dimensional symmetries underlying mammalian grid-cell activity patterns

eLife, 2015
Lattices abound in nature—from the crystal structure of minerals to the honey-comb organization of ommatidia in the compound eye of insects. These arrangements provide solutions for optimal packings, efficient resource distribution, and cryptographic ...
Alexander Mathis, Martin B Stemmler, Andreas VM Herz   +2 more
doaj   +1 more source

The broadband power shifts in entorhinal EEG are related to the firing of grid cells

Heliyon, 2021
The relationship between the firing of the grid cell and mesoscopic neural oscillations is one of the key issues to understand the neural mechanism of grid cells. Previous studies have focused more on the correspondence between neuronal firing and phases
Wenjing Wang
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Beyond correlation: optimal transport metrics for characterizing representational stability and remapping in neurons encoding spatial memory

Frontiers in Cellular Neuroscience
IntroductionSpatial representations in the entorhinal cortex (EC) and hippocampus (HPC) are fundamental to cognitive functions like navigation and memory.
Andrew Aoun, Andrew Aoun, Oliver Shetler, Oliver Shetler, Radha Raghuraman, Radha Raghuraman, Gustavo A. Rodriguez, Gustavo A. Rodriguez, S. Abid Hussaini, S. Abid Hussaini   +9 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Robust and efficient coding with grid cells

PLOS Computational Biology, 2017
Abstract The neuronal code arising from the coordinated population activity of grid cells in the rodent entorhinal cortex can uniquely represent space across large distances but the precise conditions for efficient coding are unknown. Here we present a number-theoretic analysis of grid coding and derive an upper bound on the distance ...
Lajos Vágó, Balázs Ujfalussy
openaire   +4 more sources

Grid Cells, Border Cells and Discrete Complex Analysis

Frontiers in Computational Neuroscience, 2023
We propose a mechanism enabling the appearance of border cells—neurons firing at the boundaries of the navigated enclosures. The approach is based on the recent discovery of discrete complex analysis on a triangular lattice, which allows constructing discrete epitomes of complex-analytic functions and making use of their inherent ability to attain ...
openaire   +5 more sources

Framing of grid cells within and beyond navigation boundaries

eLife, 2017
Grid cells represent an ideal candidate to investigate the allocentric determinants of the brain’s cognitive map. Most studies of grid cells emphasized the roles of geometric boundaries within the navigational range of the animal. Behaviors such as novel
Francesco Savelli, JD Luck, James J Knierim   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source