Results 41 to 50 of about 818,302 (255)
A geometric attractor mechanism for self-organization of entorhinal grid modules
eLife, 2019 Grid cells in the medial entorhinal cortex (MEC) respond when an animal occupies a periodic lattice of ‘grid fields’ in the environment. The grids are organized in modules with spatial periods, or scales, clustered around discrete values separated on ...
Louis Kang, Vijay Balasubramanian
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Disrupting the Grid Cells’ Need for Speed [PDF]
Neuron, 2016 Hinman et al. demonstrate the presence of two speed signals in the rodent medial entorhinal cortex that are differentially affected by muscimol inactivation of medial septum. The results reveal important constraints on several computational models of grid cell firing.
Hayman, R, Burgess, N
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A principle of economy predicts the functional architecture of grid cells
eLife, 2015 Grid cells in the brain respond when an animal occupies a periodic lattice of ‘grid fields’ during navigation. Grids are organized in modules with different periodicity.
Xue-Xin Wei +2 more
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On the optimality of grid cells
CoRR, 2016 Grid cells, discovered more than a decade ago [5], are neurons in the brain of mammals that fire when the animal is located near certain specific points in its familiar terrain. Intriguingly, these points form, for a single cell, a two-dimensional triangular grid, not unlike our Figure 3.
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Identifying Core Regions for Path Integration on Medial Entorhinal Cortex of Hippocampal Formation
Brain Sciences, 2020 Path integration is one of the functions that support the self-localization ability of animals. Path integration outputs position information after an animal’s movement when initial-position and movement information is input.
Ayako Fukawa +3 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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A new direction for grid cells [PDF]
Learning & Behavior, 2015 Krupic, Bauza, Burton, Barry, & O'Keefe (Grid cell symmetry is shaped by environmental geometry. Nature, 518, 232-235, 2015) found that the grids of grid cells in the entorhinal cortex of rats become sparser at the sharp end of a trapezoidal space. This makes grids, and grid cells, unsuitable for measuring distance traveled (odometry) and suggests that
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To be a Grid Cell: Shuffling procedures for determining “Gridness” [PDF]
, 2017 Abstract Grid cells in freely behaving mammals are defined by the strikingly regular periodic spatial distribution of their firing. The standard method of identification calculates the “Gridness” of the spatial firing pattern, with significance being defined relative to the 95 th ...
Barry, C., Burgess, N.
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Hippocampal Remapping and Its Entorhinal Origin
Frontiers in Behavioral Neuroscience, 2018 The activity of hippocampal cell ensembles is an accurate predictor of the position of an animal in its surrounding space. One key property of hippocampal cell ensembles is their ability to change in response to alterations in the surrounding environment,
Patrick Latuske +3 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
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