Results 51 to 60 of about 818,302 (255)
Grid cells: the missing link in understanding Parkinson’s disease?
Frontiers in NeuroscienceThe mechanisms underlying Parkinson’s disease (PD) are complex and not fully understood, and the box-and-arrow model among other current models present significant challenges. This paper explores the potential role of the allocentric brain and especially
Alexander Reinshagen
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Differences in Visual-Spatial Input May Underlie Different Compression Properties of Firing Fields for Grid Cell Modules in Medial Entorhinal Cortex. [PDF]
PLoS Computational Biology, 2015 Firing fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers.
Florian Raudies, Michael E Hasselmo
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Modeling grid fields instead of modeling grid cells [PDF]
, 2018 A neuron’s firing correlates are defined as the features of the external world to which its activity is correlated. In many parts of the brain, neurons have quite simple such firing correlates. A striking example are grid cells in the rodent medial entorhinal cortex: their activity correlates with the animal’s position in space, defining ‘grid fields ...
Sophie Rosay +2 more
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Unique grid cell identification of Croatian official map grids [PDF]
Journal of Maps, 2014 The Unique Grid Cell Identification (UGCI) system was created using the Croatian cartographic map grid system as a basis for development. A short description of the Croatian map grid system is therefore provided. Cartographic map nomenclature is used to uniquely identify map sheets; e.g. grid cells.
Duplančić Leder, Tea +2 more
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Spatial cell firing during virtual navigation of open arenas by head-restrained mice
eLife, 2018 We present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, compatible with multi-photon imaging. This system allows expression of the spatial navigation and neuronal firing patterns characteristic of real open ...
Guifen Chen +4 more
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Grid-cell representations in mental simulation. [PDF]
Elife, 2016 Anticipating the future is a key motif of the brain, possibly supported by mental simulation of upcoming events. Rodent single-cell recordings suggest the ability of spatially tuned cells to represent subsequent locations. Grid-like representations have been observed in the human entorhinal cortex during virtual and imagined navigation.
Bellmund JL +3 more
europepmc +7 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
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