Results 81 to 90 of about 1,231,821 (322)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

What grid cells convey about rat location [PDF]

, 2008
We characterize the relationship between the simultaneously recorded quantities of rodent grid cell firing and the position of the rat. The formalization reveals various properties of grid cell activity when considered as a neural code for representing ...
Brookings, Ted, Burak, Yoram, Fiete, Ila R.   +2 more
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A comparison between grid and particle methods on the statistics of driven, supersonic, isothermal turbulence

, 2010
We compare the statistics of driven, supersonic turbulence at high Mach number using FLASH a widely used Eulerian grid-based code and PHANTOM, a Lagrangian SPH code at resolutions of up to 512^3 in both grid cells and SPH particles.
Ballesteros-Paredes, Ballesteros-Paredes, Bartosch, Beetz, Berger, Boldyrev, Calder, Christoph Federrath, Colella, Daniel J. Price, Dib, Dimonte, Dubey, Elmegreen, Elmegreen, Elmegreen, Eswaran, Falgarone, Federrath, Federrath, Federrath, Fryxell, Heitmann, Hennebelle, Heyer, Hily-Blant, Kitsionas, Klessen, Klessen, Kolmogorov, Kritsuk, Kritsuk, Krumholz, Larson, Lemaster, Mac Low, Mac Low, McKee, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Nordlund, Padoan, Padoan, Padoan, Padoan, Passot, Porter, Price, Price, Price, Price, Price, Salpeter, Schmidt, Schmidt, Schmidt, She, Solomon, Vazquez-Semadeni, Vázquez-Semadeni, Zuckerman   +63 more
core   +1 more source

Distributed multi-agent algorithm for residential energy management in smart grids [PDF]

, 2012
Distributed renewable power generators, such as solar cells and wind turbines are difficult to predict, making the demand-supply problem more complex than in the traditional energy production scenario.
De Turck, Filip, Develder, Chris, Mets, Kevin, Roelens, Thomas, Strobbe, Matthias, Verschueren, Tom   +5 more
core   +1 more source

The self-organization of grid cells in 3D

eLife, 2015
Do we expect periodic grid cells to emerge in bats, or perhaps dolphins, exploring a three-dimensional environment? How long will it take? Our self-organizing model, based on ring-rate adaptation, points at a complex answer. The mathematical analysis leads to asymptotic states resembling face centered cubic (FCC) and hexagonal close packed (HCP ...
Stella, Federico, Treves, Alessandro
openaire   +5 more sources

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Size Matters: How Scaling Affects the Interaction between Grid and Border Cells

Frontiers in Computational Neuroscience, 2017
Many hippocampal cell types are characterized by a progressive increase in scale along the dorsal-to-ventral axis, such as in the cases of head-direction, grid and place cells.
Diogo Santos-Pata, Riccardo Zucca, Sock C. Low, Paul F. M. J. Verschure, Paul F. M. J. Verschure, Paul F. M. J. Verschure   +5 more
doaj   +1 more source

Characterization of Nitinol Produced by Laser Powder Bed Fusion for Mechanical Metamaterial Applications

Advanced Engineering Materials, EarlyView.
Stabilization of L‐PBF Ni50.7Ti49.3 under low‐cycle loading was investigated. Recoverable strain after cycling was dependent on the amount of applied load. Recovery ratio was 53.4% and 35.1% at intermediate and high load, respectively. The maximum total strain reached 10.3% at a high load of 1200 MPa.
Ondřej Červinek, Jakub Hurník, Miroslav Šmíd, Ondřej Zobač, Melanie Todt, Daniel Koutný   +5 more
wiley   +1 more source

Parallel grid library for rapid and flexible simulation development

, 2012
We present an easy to use and flexible grid library for developing highly scalable parallel simulations. The distributed cartesian cell-refinable grid (dccrg) supports adaptive mesh refinement and allows an arbitrary C++ class to be used as cell data ...
Honkonen, I., Janhunen, P., Palmroth, M., Sandroos, A., von Alfthan, S.   +4 more
core   +1 more source