Results 101 to 110 of about 35,246 (224)

(De)composing sociality: Disentangling individual‐specific from dyad‐specific propensities to interact

Methods in Ecology and Evolution, EarlyView.
Abstract In group‐living animals, relationships between group members are often highly differentiated. Some dyads can maintain strong and long‐lasting relationships, while others are only connected by weak or fleeting ties. More and more studies show that aspects of social relationships are related to reproductive success and survival.
Christof Neumann, Julia Fischer
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Expression of the CXCR4 S338X Variant Improves Anti‐Leukemia Efficacy of Anti‐CD19 CAR‐T Cells

Cancer Science, EarlyView.
Under normal conditions, CXCL12 stimulation induces CXCR4 degradation. In contrast, CAR19‐T cells expressing the CXCR4 S338X variant maintain receptor stability and sustain ERK and AKT signaling, which supports T‐cell effector function, migration, and survival. Therefore, the enhanced anti‐leukemic activity is conferred by CXCR4 S338X expression in CAR‐
Yushu Mao, Xiaodan Wang, Chun‐Hui Jin, Zhifeng Wei, Qinghao Ding, Ke‐Ke Zhang, Bo‐Wen Dong, Kai‐Wen Zheng, Yufei Hou, Tao Zhang, Wen‐Jie Zhao, Zheng Hu, Yong‐Guang Yang   +12 more
wiley   +1 more source

How much biotic nativeness matters across human demographic groups

Conservation Biology, EarlyView.
Abstract Many central concepts of conservation biology—such as nativeness—are structured by ecological and social factors. However, the social consequences of using these concepts to make conservation decisions remain inadequately understood. Some researchers argue that nativeness, rather than acting as an objective proxy for important ecological ...
Harold N. Eyster, Rachelle K. Gould
wiley   +1 more source

Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation

The FEBS Journal, EarlyView.
The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott, Jui‐Hung Weng, Valeria Pane, Yuliang Ma, Jian Wu, Susan S. Taylor, Friedrich W. Herberg   +6 more
wiley   +1 more source

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake

Pharmacology Research & Perspectives
Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response.
Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Sebastian Furness, Nicholas D. Holliday, Bronwyn A. Evans, Roger J. Summers, Dana S. Hutchinson   +9 more
doaj   +1 more source

Division of Labor Over the Life Course: Structural or Symbolic Pressures?

Journal of Marriage and Family, EarlyView.
ABSTRACT Objective Do structural or symbolic pressures, as measured by work‐family transitions, play a greater role in determining the gendered division of household labor? Background Scholars explain gendered divisions of household labor using structural (i.e., resource allocation; time availability) and symbolic explanations (i.e., gender as a social
Jaclyn A. Tabor, Cassie Mead, Jamie Oslawski‐Lopez, Rebecca K. Grady   +3 more
wiley   +1 more source

A Scoping Review of Instruments Used to Measure Weight and Body Composition in Infants Under 1 Year

Obesity Reviews, EarlyView.
ABSTRACT Background This scoping review identified existing outcome measurement instruments (OMIs) for weight and body composition in children ≤ 1 year of age and how they are used in clinical trials. This information will improve outcome selection in future trials.
Reindolf Anokye, Moira Duffy, Eibhlin Looney, Catherine S. Birken, Vicki Brown, Darren Dahly, Ann S. Doherty, Dimity Dutch, Rebecca K. Golley, Catherine Hayes, Brittany J. Johnson, Patricia Leahy‐Warren, Marian McBride, Elizabeth McCarthy, Andrew W. Murphy, Sarah Redsell, Caroline B. Terwee, Karen Matvienko‐Sikar   +17 more
wiley   +1 more source

Precarious agency: The role of uptake

The Southern Journal of Philosophy, EarlyView.
Abstract How do we overcome the agency dilemma, that is, account for the fact that power relations heavily affect our agency without neglecting the many ways in which oppressed people act meaningfully? This article offers a solution by paying special attention to socially complex uptake in a framework of communities of practice. In order to explain the
Deborah Mühlebach
wiley   +1 more source