Results 251 to 260 of about 44,236 (298)

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, Volume 255, Issue 9, Page 845-866, September 2026.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Cross-Strain Transferability of CRISPRi Systems and Design Rules from Laboratory to Clinical <i>Escherichia coli</i> Strains. [PDF]

ACS Synth Biol
Ban H, Rondthaler SN, Lebovich M, Lora MA, Ugbesia B, Andrews LB.   +5 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Causal effect estimation from trans-regulatory single-cell CRISPR screens. [PDF]

Cell Genom
Christensen OP, Markham A, Kang H, Gabriel E, Pers TH.   +4 more
europepmc   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Targeting cancer-specific mutations with RNA-triggered chromatin shredding. [PDF]

Nature
Zeng J, Cheng Z, Chen H, Wang Z, Thompson J, Crosby KT, Han H, Singhal A, Ngo W, Xia C, Rosas-Rivera D, Zhang Z, Kang MH, Mao Y, Diolaiti ME, Lee GC, Diffley JFX, Song Y, Qiu L, Krah NM, Murthy N, Jackson RN, Liu Y, Ashworth A, Doudna JA.   +24 more
europepmc   +1 more source

In planta Processing of the SpCas9-gRNA Complex

, 2019
openaire   +1 more source

Multifactorial Analysis Identifies Conditions for Robust HCoV-OC43 Replication in Primary Human Bronchial Epithelial Cells Cultured at Air-Liquid Interface. [PDF]

Cells
Fischhaber N, Vogler J, Martan I, Michler T.   +3 more
europepmc   +1 more source

FNIP1 variants are associated with favourable metabolism in 1 million humans. [PDF]

Nature
Hindy G, Adam RC, Sosina O, Pryce D, Blair D, Herman J, Lee J, Dornbos P, Mayerhofer E, Gilly A, Hunt C, Geraghty B, Landheer K, Ganel L, Baldassari A, Zhang C, Mintah I, Sun D, Coppola A, Brown K, Nguyen T, Xia X, Regeneron Genetics Center, GHS-RGC DiscovEHR Collaboration, Penn Medicine Biobank, Colorado Center for Personalized Medicine, Mayo Clinic-RGC Project Generation, Mexico City Prospective Study, Malmö Diet and Cancer Study, Indiana University School of Medicine (Indiana-CLDB), UCLA-RGC ATLAS Collaboration, Mount Sinai Million Health Discoveries Program, UTSW-Dallas Biobank, South Asia Biobank Study, Rader DJ, Melander O, Still CD, Berumen J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR, Collins R, Tapia-Conyer R, Balasubramanian S, Jones MB, LeBlanc MG, Murphy AJ, Kyratsous CA, Overton JD, Reid JG, Abecasis GR, Marchini J, Willer C, Yancopoulos GD, Sleeman MW, Bovijn J, Locke A, Baras A, Verweij N, Gusarova V, Lotta LA.   +61 more
europepmc   +1 more source

TPST Gene Knock-Out Eliminates Tyrosine Sulfation on a Recombinant Antibody Produced in CHO Cells. [PDF]

Biotechnol J
Schulman J, Egan R, Kandari L, Madayiputhiya N, Mahon D, Tao L, Luo H, Condon K, Feder JN, Huang D, Khetan A.   +10 more
europepmc   +1 more source