Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Scaling Property of the F-AF Spin Chain Near the Exactly Solvable Point
We investigate the ground state of the $J_1$-$J_2$ spin-1/2 chain with $J_10$ in the case that the nearest-neighbor $J_1$ interaction in the $z$-direction has a weak anisotropy as $J_1 (1-\alpha)$.
Aligia +33 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Existence and multiplicity results for a coupled system of Kirchhoff type equations
This paper deals with a coupled system of Kirchhoff type equations in ${\mathbb{R}}^{3}$. Under suitable assumptions on the potential functions $V(x)$ and $W(x)$, we obtain the existence and multiplicity of nontrivial solutions when the parameter ...
Dengfeng Lü, Jianhai Xiao
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Minimal mass blow-up solutions for the $L^2$ critical NLS with inverse-square potential
We study minimal mass blow-up solutions of the focusing $L^2$ critical nonlinear Schr\"odinger equation with inverse-square potential, \[ i\partial_t u + \Delta u + \frac{c}{|x|^2}u+|u|^{\frac{4}{N}}u = 0, \] with $N\geqslant 3$ and ...
Csobo, Elek, Genoud, François
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Ground state solutions for asymptotically periodic fractional Choquard equations
This paper is dedicated to studying the following fractional Choquard equation \begin{equation*} (-\triangle)^s u+V(x)u=\left(\int_{\mathbb{R}^N}\frac{Q(y)F(u(y))}{|x-y|^\mu}\mathrm{d}y\right)Q(x)f(u), \qquad u\in H^s(\mathbb{R}^{N}), \end{equation*
Sitong Chen, Xianhua Tang
doaj +1 more source
Supersymmetric Model of a 2D Long-Range Bose Liquid
The model Hamiltonian of a two-dimensional Bose liquid (proposed earlier by Kane, Kivelson, Lee and Zhang as the Hamiltonian which has Jastrow-type wavefunctions as the ground-state solution), is shown to possess nonrelativistic supersymmetry.
Abrikosov +30 more
core +1 more source

