Results 41 to 50 of about 2,737,234 (296)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Sustainability of groundwater through community-driven distributed recharge: An analysis of arguments for water scarce regions of semi-arid India

Journal of Hydrology: Regional Studies, 2020
Study Region: Semi-Arid Regions of Marathawada, Vidarbha and Saurashtra in IndiaStudy Focus: To understand and evaluate the impact of Managed Aquifer Recharge (MAR) efforts.New Hydrological Insights for the Region: Since 1990, the Saurashtra region of ...
Praharsh M. Patel, Dipankar Saha, Tushaar Shah   +2 more
doaj   +1 more source

Thermal characteristics of longitudinal fin with Fourier and non-Fourier heat transfer by Fourier sine transforms

Scientific Reports, 2021
The quest for high-performance of heat transfer components on the basis of accommodating shapes, smaller weights, lower costs and little volume has significantly diverted the industries for the enhancement of heat dissipation with variable thermal ...
Basma Souayeh, Kashif Ali Abro
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Isolation of bacterial pathogens from chicken manure, eggshell, and sediments in Changchun City reveal high multidrug-resistant, indices of multiple antibiotic resistance, virulence determinants, and genetic variation.

The Microbe
Pathogens have exhibited the potential for acquiring multiple antibiotic resistance, including beta-lactams, carbapenems and fluoroquinolones. Understanding the transmission dynamics, antimicrobial resistance profile and genetic diversity of the ...
Abdul Razak Alhassan, Xinran Lin, Guangze Lyu, Jiawen Lu, Courage Kosi Setsoafia Saba, Jincai Ma   +5 more
doaj   +1 more source

Assessment of groundwater quality and its controlling processes in Bemetara District of Chhattisgarh State, India

Applied Water Science, 2022
Groundwater withdrawal at very fast rate poses threat on existing groundwater resources in different parts of the world. This reduction in groundwater levels significantly disturbed the natural aquifer flow rate and thereby different hydrogeochemical ...
M. K. Sharma, Mohit Kumar, D. S. Malik, Surjeet Singh, A. K. Patre, Beena Prasad, Babita Sharma, Shekhar Saini, A. K. Shukla, P. C. Das   +9 more
doaj   +1 more source

Ground-water records of Flagler, Putnam, and St. Johns Counties, Florida [PDF]

, 1963
An investigation of the geology] and ground-water resources of Flagler, Putnam, and St. Johns counties, Florida, was made during the period November 1955 through 1958 by the U. S.
Bermes, B. J., Leve, G. W., Tarver, G. R.   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source