Results 41 to 50 of about 2,571,636 (343)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Thermal characteristics of longitudinal fin with Fourier and non-Fourier heat transfer by Fourier sine transforms

open access: yesScientific Reports, 2021
The quest for high-performance of heat transfer components on the basis of accommodating shapes, smaller weights, lower costs and little volume has significantly diverted the industries for the enhancement of heat dissipation with variable thermal ...
Basma Souayeh, Kashif Ali Abro
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, Volume 19, Issue 7, Page 2056-2073, July 2025.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Calculations of groundwater recessions caused by drainage wells in arid climate taking into account the non-uniform inversion of groundwater evaporation

open access: yesCentral Asian Journal of Water Research, 2018
This article discusses dependencies to calculate the vertical drain wells taking into account evaporation inversion. In a zone near the well,where the depth of groundwater level (GWL) is below a critical level, the inversion is set as a constant value ...
Rafael Litvak
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Evaluation of Groundwater Quality for Suitability of Irrigation Purposes: A Case Study in the Udham Singh Nagar, Uttarakhand

open access: yesJournal of Chemistry, 2020
In the present study, the groundwater quality for suitability in agriculture from Udham Singh Nagar district, Uttarakhand, has been evaluated. A total of 50 groundwater samples have been collected and analysed for pH, EC, TH, HCO3−, CO32−, Cl−, SO42 ...
Kshitindra Kr. Singh   +2 more
doaj   +1 more source

Dynamical behavior of fractionalized simply supported beam: An application of fractional operators to Bernoulli-Euler theory

open access: yesNonlinear Engineering, 2021
The complex structures usually depend upon unconstrained and constrained simply supported beams because the passive damping is applied to control vibrations or dissipate acoustic energies involved in aerospace and automotive industries.
Abro Kashif Ali   +2 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Economics of Using On-farm Reservoirs to Distribute Diverted Surface Water to Depleted Ground Water Areas of the Southern Mississippi Valley Region [PDF]

open access: yes, 2000
Rapid ground water depletion has become a significant problem for parts of the Southern Mississippi River Valley. In 1997, the Arkansas Soil and Water Conservation Commission (ASWCC) declared six counties in the Grand Prairie of Arkansas critical ground ...
Cramer, Gail L.   +3 more
core   +2 more sources

Home - About - Disclaimer - Privacy