Results 41 to 50 of about 1,880,201 (344)

HLA-II-Dependent Neuroimmune Changes in Group A Streptococcal Necrotizing Fasciitis

Pathogens, 2023
Streptococcus pyogenes (Group A Streptococcus, GAS) bacteria cause a spectrum of human diseases ranging from self-limiting pharyngitis and mild, uncomplicated skin infections (impetigo, erysipelas, and cellulitis) to highly morbid and rapidly invasive ...
Ganesh Ambigapathy, Santhosh Mukundan, Kumi Nagamoto-Combs, Colin K. Combs, Suba Nookala   +4 more
doaj   +1 more source

Invasive group A Streptococcus disease in Australian children: 2016 to 2018 – a descriptive cohort study

BMC Public Health, 2019
Invasive group A Streptococcus (iGAS) disease is serious and sometimes life-threatening. The Paediatric Active Enhanced Disease Surveillance (PAEDS) Network collects voluntary notifications from seven major Australian paediatric hospitals on patients ...
J. Oliver, Elise Thielemans, A. McMinn, C. Baker, P. Britton, J. Clark, H. Marshall, C. Blyth, J. Francis, J. Buttery, A. Steer, N. Crawford, R. J. R. M. N. S. C. M. M. C. L. T. C. J. J. H. A. D. Booy Connell Dale Deverell Dinsmore Dougherty Finu, R. Booy, J. Connell, R. Dale, M. Deverell, N. Dinsmore, S. Dougherty, C. Finucane, M. Gibson, M. Gold, C. Heath, L. Hickie, T. Hutchinson, C. Jones, J. Jones, J. Kent, H. Knight, A. Kynaston, D. Lee, G. Lewis, S. Low, N. Maclean, K. Macartney, F. McDonald, N. Mclaren, J. McRae, J. Murphy, K. Meredith, M. Nissen, C. Orr, K. Orr, N. Phillips, M. Pym, J. Quinn, P. Richmond, L. Rhind, A. Roberts, C. Robins, L. Rost, J. Royle, G. Saravanos, T. Snelling, C. Talbott, S. Tan, L. Trinh, L. Vidler, M. Walker, R. West, C. Wharton, N. Wood, Y. Zurynski   +62 more
semanticscholar   +1 more source

Concurrent Brain Subregion Microgliosis in an HLA-II Mouse Model of Group A Streptococcal Skin Infection

Microorganisms, 2023
The broad range of clinical manifestations and life-threatening infections caused by the Gram-positive bacterium, Streptococcus pyogenes or Group A Streptococcus (GAS), remains a significant concern to public health, with a subset of individuals ...
Suba Nookala, Santhosh Mukundan, Bryon Grove, Colin Combs   +3 more
doaj   +1 more source

A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?

Msphere, 2019
GAS (Streptococcus pyogenes) is a leading global cause of infection-related morbidity and mortality. A modern CHIM of GAS pharyngitis could help to accelerate vaccine development and drive pathogenesis research.
J. Osowicki, Kristy I Azzopardi, Liam McIntyre, Tania Rivera-Hernández, Cheryl-lynn Y. Ong, C. Baker, C. Gillen, M. Walker, P. Smeesters, M. Davies, A. Steer   +10 more
semanticscholar   +1 more source

Recent trends in invasive group A Streptococcus disease in Victoria

Communicable diseases intelligence, 2019
Background Invasive Group A Streptococcus (iGAS) disease can cause permanent disability and death. The incidence of iGAS has increased in many developed countries since the 1980s.
J. Oliver, M. Wilmot, J. Strachan, Siobhan St. George, C. Lane, S. Ballard, M. Sait, K. Gibney, B. Howden, D. Williamson   +9 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus

mBio, 2016
Export of macromolecules via extracellular membrane-derived vesicles (MVs) plays an important role in the biology of Gram-negative bacteria. Gram-positive bacteria have also recently been reported to produce MVs; however, the composition and mechanisms ...
U. Resch, James A. Tsatsaronis, Anaïs Le Rhun, Gerald Stübiger, M. Rohde, Sergo Kasvandik, Susanne Holzmeister, Philip Tinnefeld, S. Wai, E. Charpentier   +9 more
semanticscholar   +1 more source

Increase in invasive group A streptococcal (Streptococcus pyogenes) infections (iGAS) in young children in the Netherlands, 2022

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2023
In 2022, a sevenfold increase in the number of notifiable invasive Streptococcus pyogenes (iGAS) infections among children aged 0–5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years.
B. de Gier, Niek Marchal, Ilse de Beer-Schuurman, M. T. te Wierik, M. Hooiveld, H. D. de Melker, N. V. van Sorge   +6 more
semanticscholar   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

Successful anesthesia case of emergency cesarean section complicated with pregnancy-related group: A streptococcus sepsis

Journal of Obstetric Anaesthesia and Critical Care, 2022
Pregnancy-related Group A streptococcus (GAS) sepsis is a rare, rapidly progressing life-threatening disease. Previous reports described the clinical features of pregnancy-related GAS sepsis, however, the evidence regarding general anesthesia is ...
Yuta Kawatsu, Mitsunori Miyazu, Taiki Kojima   +2 more
doaj   +1 more source