Results 61 to 70 of about 1,880,201 (344)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Playing With Fire: Proinflammatory Virulence Mechanisms of Group A Streptococcus

Frontiers in Cellular and Infection Microbiology, 2021
Group A Streptococcus is an obligate human pathogen that is a major cause of infectious morbidity and mortality. It has a natural tropism for the oropharynx and skin, where it causes infections with excessive inflammation due to its expression of ...
Shyra Wilde, Anders F. Johnson, Christopher N. LaRock, Christopher N. LaRock   +3 more
doaj   +1 more source

The Serological Grouping of Streptococcus equinus [PDF]

Journal of General Microbiology, 1962
SUMMARY: Streptococci isolated from horse faeces and corresponding to the description of Streptococcus equinus Andrewes & Horder (1906) were found to belong to the serological group D. The group D antigen was produced by all the strains examined, but was not always extractable from whole organisms by HCI or formamide; broken organisms, however, always ...
P. M. F. Shattock, D. G. Smith
openaire   +3 more sources

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG)

Italian Journal of Pediatrics
Sore throat represents one of the main causes of antibiotic overprescription in children. Its management is still a matter of debate, with countries considering streptococcal pharyngotonsillitis a benign and self-limiting condition and others advocating ...
Elena Chiappini, Giovanni Simeone, Marcello Bergamini, Roberta Pellegrino, Alfredo Guarino, Annamaria Staiano, Susanna Esposito, Guido Castelli Gattinara, Andrea Lo Vecchio, Stefania Stefani, Iride Dello Iacono, Immacolata Scotese, Giovanna Tezza, Giulio Dinardo, Simona Riccio, Sofia Pellizzari, Sonia Iavarone, Giulia Lorenzetti, Elisabetta Venturini, Daniele Donà, Luca Pierantoni, Mattia Doria, Silvia Garazzino, Fabio Midulla, Claudio Cricelli, Luigi Terracciano, Annalisa Capuano, Eugenia Bruzzese, Daniele Ghiglioni, Lara Fusani, Eleonora Fusco, Paolo Biasci, Lamberto Reggiani, Luigi Matera, Enrica Mancino, Elisa Barbieri, Antonio D’Avino, Laura Cursi, Maria Giuseppa Sullo, Silvestro Scotti, Gian Luigi Marseglia, Giuseppe Di Mauro, Nicola Principi, Luisa Galli, Maria Carmen Verga   +44 more
doaj   +1 more source

Invasive Group A Streptococcus Infection among Children, Rural Kenya

Emerging Infectious Diseases, 2016
To determine the extent of group A Streptococcus (GAS) infections in sub-Saharan Africa and the serotypes that cause disease, we analyzed surveillance data for 64,741 hospital admissions in Kilifi, Kenya, during 1998–2011.
Anna C. Seale, Mark R. Davies, Kirimi Anampiu, Susan C. Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R. Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N. Williams, J. Anthony G. Scott, Samuel Kariuki, Gordon Dougan, James A. Berkley   +14 more
doaj   +1 more source

Group A Streptococcus Primary Peritonitis in Children, New Zealand

Emerging Infectious Diseases, 2023
Group A Streptococcus (GAS) primary peritonitis is a rare cause of pediatric acute abdomen (sudden onset of severe abdominal pain); only 26 pediatric cases have been reported in the English language literature since 1980.
Amanda Taylor, Brodie M. Elliott, John Atkinson, Sally Roberts, Lesley Voss, Emma J. Best, Rachel Webb   +6 more
doaj   +1 more source

Group A Streptococcus encounters with host macrophages.

Future Microbiology, 2018
Group A Streptococcus (GAS) is a leading human bacterial pathogen with diverse clinical manifestations. Macrophages constitute a critical first line of host defense against GAS infection, using numerous surface and intracellular receptors such as Toll ...
J. A. Valderrama, Victor Nizet, Victor Nizet   +2 more
semanticscholar   +1 more source

Pathogenesis of Hypervirulent Group A Streptococcus [PDF]

Japan Journal of Medicine, 2018
Group A Streptococcus (GAS) causes common pharyngitis and skin infections and occasional severe invasive infections. This review describes the recent progress on the pathogenesis of hypervirulent GAS. CovRS mutations are frequent among invasive GAS isolates and lead to hypervirulence. GAS CovRS mutants can be selected in vivo by neutrophils.
Mengyao Liu, Benfang Lei
openaire   +2 more sources

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source