Results 61 to 70 of about 388,097 (360)

Pathogenesis of Hypervirulent Group A Streptococcus [PDF]

Japan Journal of Medicine, 2018
Group A Streptococcus (GAS) causes common pharyngitis and skin infections and occasional severe invasive infections. This review describes the recent progress on the pathogenesis of hypervirulent GAS. CovRS mutations are frequent among invasive GAS isolates and lead to hypervirulence. GAS CovRS mutants can be selected in vivo by neutrophils.
Mengyao Liu, Benfang Lei
openaire   +2 more sources

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Prevalent emm Types among Invasive GAS in Europe and North America since Year 2000

Frontiers in Public Health, 2018
BackgroundStreptococcus pyogenes or group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections, from uncomplicated to more severe and invasive diseases with high mortality and morbidity.
Giovanni Gherardi, Luca Agostino Vitali, Roberta Creti   +2 more
doaj   +1 more source

Group A Streptococcus Is Still at Large

Journal of Clinical Medicine, 2023
Group A Streptococcus (GAS) is a major human pathogen that can cause diseases, ranging from mild to severe systemic and invasive diseases [...]
Qinghua Lu, Dingle Yu, Yonghong Yang
openaire   +2 more sources

Impact of bidirectional relationships between streptococcus anginosus group and host tissue matrix components on cellular activity: Role in establishment of infection [PDF]

, 2003
This paper investigates pathogenic mechanisms of the Streptococcus anginosus group (SAG) of bacteria which influence the biological activity of periodontal ligament (PDL) cells, endothelial cells and also how matrix proteins produced by these host cells ...
Waddington, Rachel J., Landrygan-Bakri, Janine, Wilson, Melanie, Williams, David W., Lewis, Michael Alexander Oxenham   +4 more
core   +10 more sources

Graphene–Catechol Dental Sealant: Antibacterial and Mechanical Evaluation

Advanced Engineering Materials, EarlyView.
This study presents dental sealants made with graphene and L‐DOPA‐modified graphene. L‐DOPA enhances graphene dispersion, improving sealant properties. The material shows antibacterial activity against S. mutans and L. casei, along with high strength and elasticity.
Renata Pereira, Flávio H. B. Aguiar, Rodrigo B. E. Lins, Maria C. A. J. Mainairdi, Bruna G. Silva, Marcela A. Ferretti, Klaus Rischka   +6 more
wiley   +1 more source

Invasive Group A Streptococcus Infection among Children, Rural Kenya

Emerging Infectious Diseases, 2016
To determine the extent of group A Streptococcus (GAS) infections in sub-Saharan Africa and the serotypes that cause disease, we analyzed surveillance data for 64,741 hospital admissions in Kilifi, Kenya, during 1998–2011.
Anna C. Seale, Mark R. Davies, Kirimi Anampiu, Susan C. Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R. Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N. Williams, J. Anthony G. Scott, Samuel Kariuki, Gordon Dougan, James A. Berkley   +14 more
doaj   +1 more source

Protection of pigs against challenge with virulent Streptococcus suis serotype 2 strains by a muramidase-released protein and extracellular factor vaccine [PDF]

, 2001
The efficacy of a muramidase-released protein (MRP) and extracellular factor (EF) vaccine in preventing infection and disease in pigs challenged either with a homologous or a heterologous Streptococcus suis serotype 2 strain (MRP EF ) was compared with ...
Smith, H.E., Stockhofe Zurwieden, N., Vecht, U., Wisselink, H.J.   +3 more
core   +2 more sources

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002–2010

Emerging Infectious Diseases, 2011
Group A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence of the gene (emm) that encodes the M protein. To
Patrick R. Shea, Amy L. Ewbank, Javier H. Gonzalez-Lugo, Alexandro J. Martagon-Rosado, Juan C. Martinez-Gutierrez, Hina A. Rehman, Monica Serrano-Gonzalez, Nahuel Fittipaldi, Stephen B. Beres, Anthony R. Flores, Donald E. Low, Barbara M. Willey, James M. Musser   +12 more
doaj   +1 more source