Results 41 to 50 of about 20,354,356 (219)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Preterm infants have deficient monocyte and lymphocyte cytokine responses to Group B Streptococcus [PDF]

, 2011
Group B streptococcus GBS) is an important cause of early-and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility and worse outcomes, but their immunological responses to GBS are poorly defined.
Richmond, P., Strunk, T., Curtis, S., Simmer, K., Burgner, D., Currie, A.J., Doherty, D., Liyanage, K., Riley, K., Prescott, S.   +9 more
core  

Incidence and risk factors for postpartum infections: A Norwegian cohort study, 2012-2020. [PDF]

Acta Obstet Gynecol Scand
Nationwide registry data from 516 874 deliveries in Norway (2012–2020) show that postpartum infections are common and that endometritis/puerperal sepsis is increasing. Delivery‐related factors, especially emergency cesarean section, postpartum hemorrhage, and chorioamnionitis, show the strongest associations.
Røe K, Sørbye IK, Torkildsen CF, Engeland A, Engjom HM, Nilsen RM, Klungsøyr K.   +6 more
europepmc   +2 more sources

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Frequency and proportion n (%) of Streptococcus agalactiae (Group B Streptococcus, GBS) isolation by provinces.

, 2018
Frequency and proportion n (%) of Streptococcus agalactiae (Group B Streptococcus, GBS) isolation by provinces.
Laura M. Lasso-Rojas (6065840), Ruth N. Zadoks (433642), Claudia Cobo-Ángel (6065834), Ana S. Jaramillo-Jaramillo (6065837), Alejandro Ceballos-Márquez (6065849), Sandra B. Aguilar-Marin (6065843), Javier Sanchez (313760), Juan C. Rodriguez-Lecompte (6065846)   +7 more
core   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Group B streptococcus late-onset disease: 2003-2010.

, 2013
BACKGROUND: There is insufficient population-based data on group B streptococcus (GBS) late-onset disease (LOD). Risk factors and routes of GBS transmission are poorly understood.
Memo L, Pedna MF, PERRONE, ENRICA, BACCHI REGGIANI, MARIA LETIZIA, GBS Prevention Working Group Emilia Romagna, Creti R, Piepoli M, LANARI, MARCELLO, Contiero R, Ferrari F, Lugli L, Ciccia M, Berardi A, Rossi C, Venturelli C, TRIDAPALLI, ELISABETTA   +15 more
core   +1 more source

Cross‐protective effect of a multicomponent fusion protein vaccine during a natural episode of Streptococcus zooepidemicus respiratory disease in ponies

Equine Veterinary Journal, EarlyView.
Abstract Background Streptococcus equi subspecies zooepidemicus is a highly diverse opportunistic pathogen of horses, associated with respiratory disease and endometritis. Objectives To characterise S. zooepidemicus isolates recovered from young ponies during a natural episode of respiratory disease, and to determine if vaccination with Strangvac®, a ...
Romain Paillot, J. Richard Newton, Sonia Gonzalez Medina, Sara Frosth, Lars Frykberg, Margareta Flock, Bengt Guss, Jan‐Ingmar Flock, Andrew S. Waller   +8 more
wiley   +1 more source

Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Nature Communications, 2022
Group B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute ...
Chrispin Chaguza, Dorota Jamrozy, Merijn W. Bijlsma, Taco W. Kuijpers, Diederik van de Beek, Arie van der Ende, Stephen D. Bentley   +6 more
doaj   +1 more source

Plant‐Derived Extracts Disrupt Biofilm Formation and Quorum Sensing in Yersinia enterocolitica: Insights From GC‐MS and Molecular Docking

Food Chemistry International, EarlyView.
The graphical abstract represents how natural plant products that preferentially target the specific receptors of quorum sensing could be developed to combat biofilms linked to Yersinia enterocolitica using the potent abilities of protein–ligand complexes with high docking scores.
Rajendran Thomas, Songeeta Singha, Devarshi Bharadwaj, Abinash Kumar, Dolly Sharma, Sadhana Ojha, Hirakjyoti Das, Vivek Kumar Gupta   +7 more
wiley   +1 more source