Results 31 to 40 of about 388,991 (266)

Periods for holomorphic maps via Lefschetz numbers

Abstract and Applied Analysis, 2005
We characterise the set of fixed points of a class of holomorphic maps on complex manifolds with a prescribed homology. Our main tool is the Lefschetz number and the action of maps on the first homology group.
Jaume Llibre, Michael Todd
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Pirashvili–Richter-type theorems for the reflexive and dihedral homology theories

Comptes Rendus. Mathématique
Reflexive homology and dihedral homology are the homology theories associated to the reflexive and dihedral crossed simplicial groups respectively. The former has recently been shown to capture interesting information about $C_2$-equivariant homotopy ...
Graves, Daniel
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Proteomic Style Approach To Characterize a Grass Mix Product Reveals Potential Immunotherapeutic Benefit

World Allergy Organization Journal, 2011
Background Grass allergy immunotherapies often consist of a mix of different grass extracts, each containing several proteins of different physiochemical properties; however, the subtle contributions of each protein are difficult to elucidate. This study
Alan Bullimore, BSc, Nicola Swan, MSc, Wemimo Alawode, PhD, Murray Skinner, PhD   +3 more
doaj   +1 more source

The Homology of Warped Product Submanifolds of Spheres and Their Applications

Mathematics, 2023
The aim of the current article is to formulate sufficient conditions for the Laplacian and a gradient of the warping function of a compact warped product submanifold Σβ1+β2 in a unit sphere Sd that provides trivial homology and fundamental groups.
Lamia Saeed Alqahtani, Akram Ali, Pişcoran Laurian-Ioan, Ali H. Alkhaldi   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Unraveling chaos: A topological analysis of simplicial homology groups and their foldings

Open Mathematics
In this article, we introduce a new type of simplicial homology group called the chaotic simplicial homology group. We construct the structure of this group and obtain some types of conditional foldings and unfoldings restricted to the elements of the ...
Abu-Saleem Mohammed
doaj   +1 more source