Results 151 to 160 of about 53,280 (296)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transcriptome Analysis of <i>Plectropomus leopardus</i> Erythrocytes Reveals Transcriptional Immune Suppression Induced by <i>Vibrio harveyi</i> Infection. [PDF]

Animals (Basel)
Yang J, Li A, An Z, Zhou X, Chen Q, Zhang L, Feng K, Zeng F, Chen X, Sun B.   +9 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Physicochemical Quality and Flavor Characteristics of Sevenband Grouper (<i>Hyporthodus septemfasciatus</i>) Fillets: Effects of Boiling, Steaming, Oven Cooking, and Microwave Cooking. [PDF]

Foods
Lee S, Park S, Lim J, Lee S, Oh J.
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The Effects of Lycopene on the Growth Performance, Antioxidant Capacity, and Liver Health of Hybrid Groupers (♀ <i>Epinephelus fuscoguttatus</i> × ♂ <i>E. lanceolatus</i>) Under the Influence of Aflatoxin B1. [PDF]

Animals (Basel)
Han Y, Yao Y, Liu Y, Liu Y, Dong X.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effects of Black Soldier Fly Larval (<i>Hermetia illucens</i>) Replacement Diet on Hybrid Grouper (<i>Epinephelus lanceolatus</i> ♂ × <i>E. fuscoguttatus</i> ♀) Through a Multipronged Nutrigenomic Analysis. [PDF]

Aquac Nutr
Chen Y, Chen B, Hu J, Cao J, Zhong M, Huang H, Loh JY.   +6 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Muscle Quality Responses of Pearl Gentian Grouper (<i>Epinephelus fuscoguttatus</i> ♀ × <i>Epinephelus lanceolatus</i> ♂) to Fishmeal Replacement by Defatted Silkworm Pupae Meal: Insights from Texture, Histology, Antioxidant Status and Metabolomics. [PDF]

Foods
Feng Y, Chen J, Liu Q, Zheng Y, Xiao Z, Tan B, Tang B, Zhang S.   +7 more
europepmc   +1 more source