Results 181 to 190 of about 42,252 (260)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Lipidomics reveals the pro-viral roles of ceramides during fish nodavirus infection. [PDF]

J Virol
Zhang Y, Liu L, Lin L, Zhao Y, Xi K, Guo X, Qin Q, Huang X, Huang Y.   +8 more
europepmc   +1 more source

Sperm Characteristics of Tiger Grouper (Epinephelus fuscoguttatus), Comouflage Grouper (Epinephelus polyphekadion) and Giant Grouper (Epinephelus lanceolotus) in Controled tanks

AUSTRALIAN JOURNAL OF BASIC AND APPLIED SCIENCES, 2018
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Viral insulin/IGF-like peptides inhibit IGF-1 receptor signaling to enhance viral replication. [PDF]

Cell Rep
Chuard A, Nesarajah K, Danazumi K, Reiners K, Zhang F, Levintov L, Lubos M, Žáková L, Ruggera R, McMenamin S, Vashisth H, Jiráček J, Dimarchi R, Altindis E.   +13 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Methanotroph (<i>Methylococcus capsulatus</i>) bacteria meal, influences the intestinal microbiome, and improves intestinal barrier function and immunity in hybrid grouper (<i>Epinephelus fuscointestinetatus</i> ♀ × <i>E. lanceolatus</i> ♂). [PDF]

Anim Nutr
Zhang J, Liang W, Wang J, Longshaw M, Dong X, Yang Q, Liu H, Deng J, Tan B, Chi S.   +9 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Changes in Gonadal Sex Differentiation, Digestive Enzymes, and Growth-Related Hormone Contents in the Larval and Juvenile Black Scraper, <i>Thamnaconus modestus</i>. [PDF]

Biology (Basel)
Xu W, Liu Y, Wang J, Yang P, Wu Y, Liu L.   +5 more
europepmc   +1 more source