Results 241 to 250 of about 400,493 (285)

Dissecting Growth Cone Guidance

Science Signaling, 2003
The growth cones of developing neurons take s and turns that allow them to reach the appropriate target. Their path is guided by responses to attractive and repulsive cues from chemotropic ligands that they encounter along the way. These ligands activate receptors on the surface of the growth cone.
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Microtubules and growth cone function

Journal of Neurobiology, 2003
AbstractIt has been recognized for a long time that the neuronal cytoskeleton plays an important part in neurite growth and growth cone pathfinding, the mechanism by which growing axons find an appropriate route through the developing embryo to their target cells.
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Microtubule organization in growth cones

Biochemical Society Transactions, 1991
Neuronal growth cones guide growing axons and dendrites (neurites) through developing embryos by detecting extrinsic guidance cues and transducing the signal into changes in motile behavior. In this chapter, the role of the growth cone cytoskeleton in these events, in particular the microtubules, is discussed.
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Growth Cone Guidance

Science's STKE, 2004
The semaphorin family of guidance cues act predominantly through plexin receptors at the surface of various cell types. The small guanosine triphosphatases (GTPases) Rho and Rac have been implicated as downstream effectors of semaphorin-plexin interactions that modulate the cytoskeleton, but details of how plexins activate these GTPases ...
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Autonomous regulation of growth cone filopodia

Journal of Neurobiology, 1998
The fan-shaped array of filopodia is the first site of contact of a neuronal growth cone with molecules encountered during neuronal pathfinding. Filopodia are highly dynamic structures, and the "action radius" of a growth cone is strongly determined by the length and number of its filopodia.
V, Rehder, S, Cheng
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Directional guidance of nerve growth cones

Current Opinion in Neurobiology, 2006
The intricate connections of the nervous system are established, in part, by elongating axonal fibers that are directed by complex guidance systems to home in on their specific targets. The growth cone, the major motile apparatus at the tip of axons, explores its surroundings and steers the axon along a defined path to its appropriate target ...
Zhexing, Wen, James Q, Zheng
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Vesicular movements in the growth cone

Neurochemistry International, 2018
Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons.
Motohiro Nozumi, Michihiro Igarashi
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Growth Cones Need p53

Science Signaling, 2009
The tumor suppressor p53 may regulate Rho kinase to contribute to axonal growth cone motility.
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Cytoskeletal events in growth cone steering

Current Opinion in Neurobiology, 1994
Oriented neural outgrowth is dependent upon the capability of growth cones to reorient the direction of their migration in response to contact with guidance information. Recent observations have directed attention toward the role of actin distribution and concentration in transmitting localized peripheral signals to central elements of the growth cone,
D, Bentley, T P, O'Connor
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Growth cone calcium elevation by GABA

The Journal of Comparative Neurology, 1996
Cytoplasmic calcium plays a key role in neurite growth. In contrast to previous work suggesting that gamma aminobutyrate's (GABA) role in regulating growth cone calcium is primarily to antagonize the effects of glutamate, we report that GABA can act in an excitatory manner on developing hypothalamic neurites, independently raising calcium in growing ...
K, Obrietan, A N, van den Pol
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