Distribution of Acid Sensing Ion Channels in Axonal Growth Cones and Presynaptic Membrane of Cultured Hippocampal Neurons [PDF]
Frontiers in Cellular Neuroscience, 2020 Although acid-sensing ion channels (ASICs) are widely expressed in the central nervous system, their distribution and roles in axonal growth cones remain unclear.
Xiaoyan Liu +5 more
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Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway [PDF]
Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
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Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions [PDF]
Biomolecules, 2020 During neural development, growth cones, very motile compartments of tips of axons, lead axonal extension to the correct targets. Subsequently, presynapses, another axonal compartment with vigorous trafficking of synaptic vesicles, emerge to form ...
Yukio Sasaki
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Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway [PDF]
Frontiers in Cell and Developmental Biology, 2021 During brain development, axon outgrowth and its subsequent pathfinding are reliant on a highly motile growth cone located at the tip of the axon. Actin polymerization that is regulated by actin-depolymerizing factors homology (ADF-H) domain-containing ...
Xubin Hou +5 more
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Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones. [PDF]
PLoS Pathogens, 2022 Herpes simplex virus type 1 (HSV-1) has evolved mechanisms to exploit the host cytoskeleton during entry, replication and exit from cells. In this study, we determined the role of actin and the molecular motor proteins, myosin II and myosin V, in the ...
Kevin Danastas +5 more
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Time-Lapse Super-Resolution Imaging and Optical Manipulation of Growth Cones in Elongating Axons and Migrating Neurons [PDF]
Bio-ProtocolThe growth cone is a highly motile tip structure that guides axonal elongation and directionality in differentiating neurons. Migrating immature neurons also exhibit a growth cone–like structure (GCLS) at the tip of the leading process.
Masato Sawada +11 more
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Revisiting the Proliferated Seed Cones in Larix kaempferi Reveals a Growth Arrest Plasticity [PDF]
Plant DirectIn angiosperms, such as Arabidopsis, silique removal can reverse developmental arrest and reactivate inflorescence meristems, illustrating that post‐fertilization growth cessation is a plastic process rather than terminal differentiation.
Zha‐Long Ye +6 more
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β-catenin-α-catenin and actomyosin signaling differentially regulate growth cone contours and axon undulation and branching of retinal ganglion cells in situ [PDF]
Frontiers in Cellular NeuroscienceIntroductionCadherin adhesive and actomyosin signaling are key cytomechanical cues required for neuronal circuit formation, but whether they function together to sculpt developing neurons is not known. Previously, we demonstrated that a β-catenin mutant (
Valerie Lew +6 more
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Frontiers in Plant Science, 2023 The cone is a crucial component of the whole life cycle of gymnosperm and an organ for sexual reproduction of gymnosperms. In Pinus koraiensis, the quantity and development process of male and female cones directly influence seed production, which in ...
Yan Li +8 more
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Varicones and growth cones: two neurite terminals in PC12 cells. [PDF]
PLoS ONE, 2009 The rat adrenal pheochromocytoma PC12 cell line is one of the traditional models for the study of neurite outgrowth and growth cone behavior. To clarify to what extent PC12 neurite terminals can be compared to neuronal growth cones, we have analyzed ...
Ana Mingorance-Le Meur +2 more
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