Distribution of Acid Sensing Ion Channels in Axonal Growth Cones and Presynaptic Membrane of Cultured Hippocampal Neurons [PDF]
Frontiers in Cellular Neuroscience, 2020 Although acid-sensing ion channels (ASICs) are widely expressed in the central nervous system, their distribution and roles in axonal growth cones remain unclear.
Xiaoyan Liu +5 more
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Regulation of chemotropic guidance of nerve growth cones by microRNA [PDF]
Molecular Brain, 2011 Background The small non-coding microRNAs play an important role in development by regulating protein translation, but their involvement in axon guidance is unknown.
Han Liang +7 more
doaj +3 more sources
Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway [PDF]
Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
doaj +2 more sources
Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions [PDF]
Biomolecules, 2020 During neural development, growth cones, very motile compartments of tips of axons, lead axonal extension to the correct targets. Subsequently, presynapses, another axonal compartment with vigorous trafficking of synaptic vesicles, emerge to form ...
Yukio Sasaki
doaj +2 more sources
Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway [PDF]
Frontiers in Cell and Developmental Biology, 2021 During brain development, axon outgrowth and its subsequent pathfinding are reliant on a highly motile growth cone located at the tip of the axon. Actin polymerization that is regulated by actin-depolymerizing factors homology (ADF-H) domain-containing ...
Xubin Hou +5 more
doaj +2 more sources
Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones. [PDF]
PLoS Pathogens, 2022 Herpes simplex virus type 1 (HSV-1) has evolved mechanisms to exploit the host cytoskeleton during entry, replication and exit from cells. In this study, we determined the role of actin and the molecular motor proteins, myosin II and myosin V, in the ...
Kevin Danastas +5 more
doaj +2 more sources
Morphology and nanomechanics of sensory neurons growth cones following peripheral nerve injury. [PDF]
PLoS ONE, 2013 A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
Marta Martin +7 more
doaj +7 more sources
Time-Lapse Super-Resolution Imaging and Optical Manipulation of Growth Cones in Elongating Axons and Migrating Neurons [PDF]
Bio-ProtocolThe growth cone is a highly motile tip structure that guides axonal elongation and directionality in differentiating neurons. Migrating immature neurons also exhibit a growth cone–like structure (GCLS) at the tip of the leading process.
Masato Sawada +11 more
doaj +2 more sources
Regulation of patterned dynamics of local exocytosis in growth cones by netrin-1. [PDF]
J Neurosci, 2015 Axonal guidance and synaptic specification depends on specific signaling mechanisms that occur in growth cones. While several signaling pathways implicated in cone navigation have been identified, membrane dynamics in growth cones remains largely unknown.
Ros O +3 more
europepmc +4 more sources
FLIM FRET Visualization of Cdc42 Activation by Netrin-1 in Embryonic Spinal Commissural Neuron Growth Cones. [PDF]
PLoS ONE, 2016 Netrin-1 is an essential extracellular chemoattractant that signals through its receptor DCC to guide commissural axon extension in the embryonic spinal cord.
Benjamin Rappaz +4 more
doaj +2 more sources