Morphology and nanomechanics of sensory neurons growth cones following peripheral nerve injury. [PDF]
PLoS ONE, 2013 A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
Marta Martin +7 more
doaj +7 more sources
Regulation of chemotropic guidance of nerve growth cones by microRNA [PDF]
Molecular Brain, 2011 Background The small non-coding microRNAs play an important role in development by regulating protein translation, but their involvement in axon guidance is unknown.
Han Liang +7 more
doaj +5 more sources
Regulation of patterned dynamics of local exocytosis in growth cones by netrin-1. [PDF]
J Neurosci, 2015 Axonal guidance and synaptic specification depends on specific signaling mechanisms that occur in growth cones. While several signaling pathways implicated in cone navigation have been identified, membrane dynamics in growth cones remains largely unknown.
Ros O +3 more
europepmc +4 more sources
Specifics of growth by diameter of red male cones and yellow male cones forms of Scots pine [PDF]
Сибирский лесной журнал, 2020 Ecotopic analysis of the Scots pine Pinus sylvestris L. population structure based on the ratio of intraspecific forms – red male cones P. s. f. erythranthera Sanio and yellow male cones P. s. f.
A. E. Konovalova +2 more
doaj +1 more source
Differences in protein mobility between pioneer versus follower growth cones [PDF]
, 2007 Navigating growth cones need to integrate, process and respond to guidance signals, requiring dynamic information transfer within and between different compartments.
Bak +25 more
core +3 more sources
iScience, 2020 Summary: During neurodevelopment, the growth cone deciphers directional information from extracellular guidance cues presented as shallow concentration gradients via signal amplification.
Carmen Chan +8 more
doaj +1 more source
FLIM FRET Visualization of Cdc42 Activation by Netrin-1 in Embryonic Spinal Commissural Neuron Growth Cones. [PDF]
PLoS ONE, 2016 Netrin-1 is an essential extracellular chemoattractant that signals through its receptor DCC to guide commissural axon extension in the embryonic spinal cord.
Benjamin Rappaz +4 more
doaj +1 more source
An Emerging Role of PRRT2 in Regulating Growth Cone Morphology
Cells, 2021 Mutations in the PRRT2 gene are the main cause for a group of paroxysmal neurological diseases including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. In the mature central nervous system,
Elisa Savino +5 more
doaj +1 more source
Non-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factors. [PDF]
PLoS ONE, 2014 Non-muscle myosin II (NM II) regulates a wide range of cellular functions, including neuronal differentiation, which requires precise spatio-temporal activation of Rho GTPases.
Eun-Young Shin +7 more
doaj +1 more source
Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies
Frontiers in Neuroscience, 2021 Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites.
Massimo M. Onesto +4 more
doaj +1 more source