Results 61 to 70 of about 1,494,529 (338)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Prenatal Neurogenesis in Autism Spectrum Disorders. [PDF]

, 2016
An ever-increasing body of literature describes compelling evidence that a subset of young children on the autism spectrum show abnormal cerebral growth trajectories.
Kaushik, Gaurav, Zarbalis, Konstantinos S   +1 more
core   +1 more source

Diagnostic Value of IL-6, CRP, WBC, and Absolute Neutrophil Count to Predict Serious Bacterial Infection in Febrile Infants

Acta Medica Iranica, 2015
Since  clinical  manifestations  of  most  febrile  infants  younger  than  three  months  old  are nonspecific, differentiation of Serious Bacterial Infection (SBI) from self-limiting viral illness is a significant challenge for pediatricians.
Marjaneh Zarkesh, Fatemeh Sedaghat, Abtin Heidarzadeh, Manizheh Tabrizi, Kobra Bolooki Moghadam, Soheil Ghesmati   +5 more
doaj  

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer’s disease

Experimental and Molecular Medicine
ELK1 is a member of the E-twenty-six transcription factor family and is usually activated by phosphorylation at Ser383 and Ser389 by extracellular signal-regulated kinase 1/2 (ERK1/2).
Lilin Yi, Junjie Li, Yan He, Jiaojiao Wang, Maoju Wang, Song Guo, Man Luo, Bin Wu, Mingliang Xu, Qiuyun Tian, Yepeng Fan, Mulan Chen, Boqing Xu, Lei Xia, Weihong Song, Guiqiong He, Yehong Du, Zhifang Dong   +17 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Growth in Disorders of Adrenal Hyperfunction

Hormone Research in Paediatrics, 2002
Growth is disturbed by adrenal hypersecretion of androgens or cortisol. Androgen excess in virilizing adrenal tumours causes advanced growth and bone age. In 9 girls with virilizing tumours, mean heights at diagnosis and final heights were 1.23 ± 0.42 and 1.3 ± 0.37 SDS respectively.
Savage, M, Scommegna, S, Carroll, P, Ho, J, Monson, J, Besser, G, Grossman, AB   +6 more
openaire   +3 more sources

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]

, 2011
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Akin C, Akin C, Akin C, Alberto Orfao, Alvarez-Twose I, Arock M, Arredondo AR, Austen KF, Awad JA, Bodemer C, Boguslaw Nedoszytko, Bonadonna P, Butterfield JH, Castells MC, Cem Akin, Chin KW, Costa JJ, Daley T, Dean D. Metcalfe, Di Lorenzo G, Donker ML, Finkelman FD, Galli SJ, Garcia-Montero AC, Golden DB, González de Olano D, Hans-Peter Horny, Hogan AD, Horny HP, Johansson SG, Jordan JH, Joseph H. Butterfield, Karin Hartmann, Karl Sotlar, Knut Brockow, Lawrence B. Schwartz, Lieberman P, Luis Escribano, Maintz L, Mariana Castells, Massimo Triggiani, Melody C. Carter, Metcalfe DD, Metcalfe DD, Metcalfe DD, Michel Arock, Morel AM, Murphy S, Nedoszytko B, Peavy RD, Peter Valent, Philip Lieberman, Rivera J, Rudolf Valenta, Ruëff F, Samorapoompichit P, Sampson HA, Schwartz LB, Schwartz LB, Schwartz LB, Schwelberger HG, Serafin WE, Sonneck K, Sperr WR, Vadas P, Valent P, Valent P, Valent P, Valent P, Valent P, van der Donk EM, van Toorenenbergen AW, Webb LM, Wolfgang R. Sperr   +73 more
core   +1 more source

IMPLEMENTATION OF STUNTING PROGRAM IN INDONESIA: A NARRATIVE REVIEW

Jurnal Administrasi Kesehatan Indonesia, 2022
Background: Stunting is one of the nutritional problems in the world, especially in Indonesia. Aims: This study aimed to describe the implementation of stunting programs in Indonesia, Related to specific and sensitive nutrition interventions in ...
Siti Zaleha, Haerawati Idris
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source