Results 111 to 120 of about 7,031,181 (311)

Uncovering Thyroid Vulnerability to Doxorubicin: Integrative Cellular and in vivo Evidence of Mitochondrial Dysfunction

Drug Design, Development and Therapy
Weiqiang Huang,1,* Yongpan Wang,1,* Hanbing Wang,2 Rongbing Chen,3 Haiqing Gu,1 Shunyan Yu,1 Ziwei Bao,4 Li Luo,5 Da Sun,6 Binjiao Zheng7 1Thyroid and Breast Surgery, The First People`s Hospital of Jiashan, Jiashan Hospital Affiliated to ...
Huang W, Wang Y, Wang H, Chen R, Gu H, Yu S, Bao Z, Luo L, Sun D, Zheng B   +9 more
doaj  

Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Clinical, Cosmetic and Investigational Dermatology, 2016
Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2 1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France *These authors contributed equally to this work Abstract: Skin aging is primarily due to alterations in ...
Aldag C, Nogueira Teixeira D, Leventhal PS   +2 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering

International Journal of Nanomedicine, 2020
Li Chen,1,2,* Jiaxin Liu,1,* Ming Guan,2,3 Tongqing Zhou,2 Xin Duan,1 Zhou Xiang1 1Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of ...
Chen L, Liu J, Guan M, Zhou T, Duan X, Xiang Z   +5 more
doaj  

Nerve growth factor [PDF]

, 1988
Bandtlow, C. E., Heumann, R., Lindholm, D., Meyer, Michael, Rohrer, H., Thoenen, Hans   +5 more
core   +1 more source

Total Factor Productivity Growth and the Environment: A Case for Green Growth Accounting [PDF]

We examine whether the use of the environment, proxied by CO2 emissions, as a factor of production contributes, in addition to con- ventional factors of production to output growth, and thus it should be accounted for in total factor productivity growth (
Anastasios Xepapadeas, Dimitra Vouvaki, Vangelis Tzouvelekas   +2 more
core  

Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. [PDF]

, 1984
Plasma membranes derived from NR-6 cells, a variant line of Swiss mouse 3T3 cells that does not have cell surface receptors for epidermal growth factor (EGF), inhibited EGF-induced stimulation of DNA synthesis by 50% in serum-starved, subconfluent 3T3 ...
Fox, CF, Matiuck, NV, Peterson, SW, Vale, RD   +3 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source