Results 201 to 210 of about 11,216,259 (234)

Fibroblast Growth Factor 2-Immobilized Biointerfaces Drive Exogenous Transforming Growth Factor β1-Independent Chondrogenesis of Human Mesenchymal Stem Cell and Ectopic Cartilage Tissue Formation. [PDF]

Biomater Res
Jeong JH, Park JH, Ban MJ, Lee Y, Kim H, Kim Y, Kim G, Kwon SW, Lee JH, Kim SH, Hwang Y.   +10 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Clinical immunogenicity and pharmacokinetic assessments of E3112, a recombinant human hepatocyte growth factor. [PDF]

Future Sci OA
Aoyama M, Takanohashi T, Ohba F, Mano Y.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Epidermal growth factor receptor modulation for neural repair: Implications for neurodegenerative disease therapy. [PDF]

Front Mol Neurosci
Amin A, Badenes M.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Insulin-like Growth Factor Signaling Promotes Corneal Myofibroblast Survival and Sustains Corneal Fibrosis. [PDF]

Int J Mol Sci
Hwang Y, Son KN, Chaudhary M, Lee E, Kim M, You S, Smith TJ, Aakalu VK, Han KY.   +8 more
europepmc   +1 more source

Expression of Growth Factor Genes in the Body Wall of the Holothurian Eupentacta fraudatrix During Regenerative Processes. [PDF]

Genesis
Girich AS.
europepmc   +1 more source

Placental Growth Factor in Diabetic Retinopathy: Disease-Selective Signaling and Mechanistic Rationale for Targeted Therapy. [PDF]

Int J Mol Sci
Kim J, Ju WK, Won JY.
europepmc   +1 more source

Histological Evaluation of Insulin-like Growth Factor-I in Experimental Intestinal Ischemia-Reperfusion Injury: A Rat Study. [PDF]

Diseases
Andronikou A, Psalla D, Ioannidis R, Papalois A, Iliadis S, Dinaki K, Kamparoudis A.   +6 more
europepmc   +1 more source