Results 271 to 280 of about 2,830,094 (317)
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Growth Factors and Growth Factor Inhibitors
1997This chapter will outline novel treatment strategies predicated on the modulation of growth factor or cytokine-mediated signal transduction pathways. Several excellent recent monographs have addressed this tissue from the point of view of inhibitors of individual pathway constituents (1,2).The current focus will be on defining the pathways potentially ...
Edward A. Sausville, Dan L. Longo
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The International journal of developmental biology, 1999
Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechanisms that direct cell proliferation and differentiation.
de Laat, S.W. +7 more
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Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechanisms that direct cell proliferation and differentiation.
de Laat, S.W. +7 more
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Growth factors and growth factor receptors.
British journal of hospital medicine, 1993Peptide growth factors and their cell surface-associated receptors are important determinants of normal and pathological growth reactions. Through signal transduction pathways, receptor occupancy triggers the production of intracellular downstream effector molecules which ultimately cause cell proliferation.
M R, Alison, N A, Wright
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Cell Biology International, 1995
ABSTRACTKeratinocyte growth factor (KGF) is a member of the heparin‐binding fibroblast growth factor family (FGF‐7) with a distinctive pattern of target‐cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a variety of tissues. In contrast, KGF was produced solely by cells
Jeffrey S. Rubin +10 more
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ABSTRACTKeratinocyte growth factor (KGF) is a member of the heparin‐binding fibroblast growth factor family (FGF‐7) with a distinctive pattern of target‐cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a variety of tissues. In contrast, KGF was produced solely by cells
Jeffrey S. Rubin +10 more
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Clinical Orthopaedics and Related Research, 1991
Bone volume is determined by the relative rates of bone formation and bone resorption. Recent research in several laboratories suggests that growth factors may act locally to modulate bone formation by stimulating osteoblast proliferation and activity.
S, Mohan, D J, Baylink
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Bone volume is determined by the relative rates of bone formation and bone resorption. Recent research in several laboratories suggests that growth factors may act locally to modulate bone formation by stimulating osteoblast proliferation and activity.
S, Mohan, D J, Baylink
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Hepatology, 1992
The two papers in this issue of Hepatology (1, 2) dealing with hepatocyte growth factor (HGF) underscore the increasing importance of this novel growth factor in relation to hepatic growth biology. The emerging literature has already established HGF as a growth factor with potential importance not only for the liver but for ...
G K, Michalopoulos, R, Zarnegav
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The two papers in this issue of Hepatology (1, 2) dealing with hepatocyte growth factor (HGF) underscore the increasing importance of this novel growth factor in relation to hepatic growth biology. The emerging literature has already established HGF as a growth factor with potential importance not only for the liver but for ...
G K, Michalopoulos, R, Zarnegav
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Nature, 1974
FREE-living nematodes, grown axenically in a chemically defined medium, might be of considerable interest as model systems for studying the fundamental aspects of genetics and differentiation of higher organisms.
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FREE-living nematodes, grown axenically in a chemically defined medium, might be of considerable interest as model systems for studying the fundamental aspects of genetics and differentiation of higher organisms.
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Medical Journal of Australia, 1988
Erythropoietin, GM-colony-stimulating factor and G-colony-stimulating factor are the first recombinant haemopoietic growth factors to reach clinical use. There are a number of additional haemopoietic regulators that have now been cloned and are being mass-produced with a view to clinical use.
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Erythropoietin, GM-colony-stimulating factor and G-colony-stimulating factor are the first recombinant haemopoietic growth factors to reach clinical use. There are a number of additional haemopoietic regulators that have now been cloned and are being mass-produced with a view to clinical use.
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Growth factors and growth control
Current Opinion in Cell Biology, 1990Polypeptide growth factors are thought to govern a variety of physiological processes such as cell growth, differentiation, embryogenesis, hematopoiesis, and wound repair. Although it is well documented that growth factors are required for cell proliferation in tissue-culture systems, current knowledge of their in uivo functions is still meager.
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