Results 281 to 290 of about 26,786,639 (354)
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Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
Endocrine Reviews, 1995John I. Jones, D. Clemmons
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Annals of Internal Medicine, 1980
Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of ...
DAVID W. GOLDE +3 more
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Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of ...
DAVID W. GOLDE +3 more
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Endocrine Pathology, 1997
Growth factors are polypeptides that interact with specific cellular receptors leading to many different biological responses. There are various families of growth factors that have similar biochemical structures. Although many growth factors stimulate cell proliferation, a few have primarily inhibitory functions, such as transforming growth factor-p ...
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Growth factors are polypeptides that interact with specific cellular receptors leading to many different biological responses. There are various families of growth factors that have similar biochemical structures. Although many growth factors stimulate cell proliferation, a few have primarily inhibitory functions, such as transforming growth factor-p ...
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The International Journal of Developmental Biology, 1999
Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechanisms that direct cell proliferation and differentiation.
Laat, S.W. de +7 more
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Signalling between cells in the developing vertebrate embryo is essential for normal embryonic development. In the mid 1970's, signal transduction research started at the Hubrecht Laboratory with special emphasis on analysis of the signalling mechanisms that direct cell proliferation and differentiation.
Laat, S.W. de +7 more
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Life Sciences, 1974
Publisher Summary This chapter discusses the structure of nerve growth factor (NGF). The amino acid sequence of mouse NGF exhibited significant structural relatedness with the family of insulins and proinsulins. The sequence of mouse NGF could be aligned with human proinsulin with only five deletions required to yield the maximum homology of 21 ...
L F, Boyd +6 more
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Publisher Summary This chapter discusses the structure of nerve growth factor (NGF). The amino acid sequence of mouse NGF exhibited significant structural relatedness with the family of insulins and proinsulins. The sequence of mouse NGF could be aligned with human proinsulin with only five deletions required to yield the maximum homology of 21 ...
L F, Boyd +6 more
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Growth factors and their receptors
Current Opinion in Cell Biology, 1989The growth of cells in culture is controlled by polypeptide hormones that stimulate or inhibit proliferation. More than 20 different growth factors have been extensively characterised, and the corresponding cDNAs have been cloned (Table 1). Several additional growth factors are known from their biological activities but have not yet been structurally ...
B, Westermark, C H, Heldin
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The insulin-like growth factor (IGF) system includes two peptide ligands, IGF-I and IGF-II; their receptors, the IGF-I receptor and the mannose-6-phosphate receptor, and six IGF-binding proteins.
D. Roith
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Neurological Sciences, 2003
Recent studies have provided new insights on the identity and mechanisms of action of growth factors implicated in myelination processes. Members of several different families of growth factors have been shown to affect oligodendrocyte survival, proliferation and differentiation and their manipulation in the experimental animal provides a means to ...
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Recent studies have provided new insights on the identity and mechanisms of action of growth factors implicated in myelination processes. Members of several different families of growth factors have been shown to affect oligodendrocyte survival, proliferation and differentiation and their manipulation in the experimental animal provides a means to ...
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Growth factors and growth control
Current Opinion in Cell Biology, 1990Polypeptide growth factors are thought to govern a variety of physiological processes such as cell growth, differentiation, embryogenesis, hematopoiesis, and wound repair. Although it is well documented that growth factors are required for cell proliferation in tissue-culture systems, current knowledge of their in uivo functions is still meager.
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