The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity. [PDF]
Biochem Insights, 2017 There is substantial evidence that the growth hormone (GH)/insulin-like growth factor (IGF) system is involved in the pathophysiology of obesity. Both GH and IGF-I have direct effects on adipocyte proliferation and differentiation, and this system is ...
Lewitt MS.
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Chronic inflammation and the growth hormone/insulin-like growth factor-1 axis [PDF]
Central European Journal of Immunology, 2021 Interactions between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the immune system are complex, bidirectional, but not fully explained.
Ewelina Witkowska-Sędek, Beata Pyrżak
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The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin [PDF]
Endocrinology and MetabolismThis review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important.
Eline C. Nijenhuis-Noort +3 more
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The growth hormone-insulin like growth factor axis in pregnancy. [PDF]
Journal of Endocrinology, 2021 The growth hormone (GH)-insulin-like growth factor (IGF) axis is one of the main drivers of mammalian growth and development. Pituitary secretion of GH is pulsatile and under positive and negative hypothalamic control, as well as stimulation from gastric-
H. Kaur +3 more
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Growth hormone, insulin-like growth factors, and the skeleton. [PDF]
Endocrine Reviews, 2008 GH and IGF-I are important regulators of bone homeostasis and are central to the achievement of normal longitudinal bone growth and bone mass. Although GH may act directly on skeletal cells, most of its effects are mediated by IGF-I, which is present in the systemic circulation and is synthesized by peripheral tissues.
A. Giustina, G. Mazziotti, E. Canalis
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Links Between Testosterone, Oestrogen, and the Growth Hormone/Insulin-Like Growth Factor Axis and Resistance Exercise Muscle Adaptations. [PDF]
Front Physiol, 2020 Maintenance of skeletal muscle mass throughout the life course is key for the regulation of health, with physical activity a critical component of this, in part, due to its influence upon key hormones such as testosterone, estrogen, growth hormone (GH ...
Gharahdaghi N +5 more
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The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders. [PDF]
Endocr Connect, 2018 The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the ...
Blum WF +6 more
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GROWTH HORMONE, INSULIN-LIKE GROWTH FACTOR-1 AND THE AGING BRAIN [PDF]
Experimental Gerontology, 2014 Growth hormone (GH) and insulin-like growth factor (IGF)-1 regulate the development and function of cells throughout the body. Several clinical diseases that result in a decline in physical and mental function are marked by mutations that disrupt GH or ...
Nicole M. Ashpole +4 more
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Growth hormone, insulin, and somatostatin therapy of cancer cachexia [PDF]
Cancer, 1994 Cancer cachexia is associated with a decreased insulin:glucagon ratio. The authors hypothesized that the decrease in this anabolic hormone index is largely responsible for the progressive catabolism characteristic of cancer cachexia. Previous studies of insulin therapy alone in treating cancer cachexia have yielded limited success due to insulin ...
David L. Bartlett +2 more
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Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin [PDF]
Frontiers in EndocrinologyGrowth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in healthy states. However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH ...
Kevin C. J. Yuen +9 more
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