Results 261 to 270 of about 6,173,170 (321)
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Growth hormone/insulin-like growth factor I axis in neurodegenerative diseases
Journal of Endocrinological Investigation, 2010Neurodegenerative diseases (ND) are a group of heterogeneous disorders characterized by unknown etiology, subtle onset, and progressive involvement of neuronal systems leading to degeneration and dysfunction. They represent a challenge for basic science and clinical medicine because of increasing prevalence, social cost, complex biochemistry and ...
GASPERI, Maurizio, CASTELLANO AE
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The Renal Growth Hormone/Insulin-Like Growth Factor I Axis
American Journal of Kidney Diseases, 1991Collecting duct is a major site of insulin-like growth factor-I (IGF-I) synthesis within kidney. Production of IGF-I at this site is stimulated by growth hormone (GH). IGF-I produced in collecting duct is likely to act on glomerulus and proximal tubule via IGF-I receptors present at these locations.
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Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis
Nature Reviews Endocrinology, 2022G. Mazziotti, A. Lania, E. Canalis
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Growth hormone, insulin-like growthfactor I and cognitive function in adults
Growth Hormone & IGF Research, 2000This review focuses on the possible contribution of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis to cognitive function. Binding sites for GH and IGF-I are found in various areas of the brain. Their distribution suggests that GH and IGF-I contribute to the function of the hippocampus, a brain structure important for the maintenance ...
van Dam, P.S. +6 more
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Effect of growth hormone, insulin, thyroxine and cortisone on renal gluconeogenesis
Archives of Biochemistry and Biophysics, 1968Abstract Gluconeogenesis in kidney cortical slices of rats under different conditions was studied in the presence of glutamate, pyruvate and succinate as substrates. Slices obtained from rats treated with growth hormone exhibited a marked increase in gluconeogenesis with pyruvate and succinate as substrates, but not with glutamate.
P K, Joseph, K, Subrahmanyam
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An endocrinologist's approach to the growth hormone—insulin‐like growth factor axis
Acta Paediatrica, 1997Gene knockout studies in mice, and a recent case report, have demonstrated that insulin‐like growth factors (IGFs) are major mediators of pre‐ and postnatal growth, whereas the growth‐promoting role of growth hormone (GH) appears to be confined largely to the postnatal period. The IGF axis is now known to consist of the growth factors themselves and at
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Growth Hormone, Insulin-like Growth Factor I, and Benign Intracranial Hypertension
New England Journal of Medicine, 1993To the Editor: The Food and Drug Administration, after receiving 6 reports of benign intracranial hypertension (pseudotumor cerebri) in patients treated with recombinant growth hormone, actively identified an additional 17 affected patients in the United States or abroad.
S, Malozowski +3 more
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Growth and lactogenic hormones, insulin-like growth factor and insulin
2003Abstract Prolactin (PRL), growth hormone (GH) and placental lactogenic hormones (PL) belong to the growth and lactogenic hormone (GLH) family. These hormones show molecular heterogeneity and the variant hormones differ in their biological activity. GLH receptors are also heterogeneous and have common features with hemopoietic and lymphocyte cytokine ...
Istvan Berczi, Andor Szentivanyi
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Growth Hormone, Insulin-Like Growth Factor I, and Kidney
1991Insulin-like growth factor I (IGF I) exerts a variety of actions on kidney. To shed light upon its role in regulation of renal function and renal growth we have characterized its cellular biology in two parts of the nephron, proximal tubule and collecting duct.
Marc R. Hammerman, Steven B. Miller
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The Growth Hormone Insulin-Like Growth Factor-I Axis
1997Somatotropin or growth hormone (GH) is the most abundant hormone in the human pituitary. GH is a peptide synthesized and secreted by the anterior pituitary, and is an important regulator of growth and differentiated function. Human GH differs from that of other species, including primates, making it unique among pituitary hormones; whereas ...
Arvind Y. Krishna, Lawrence S. Phillips
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