Results 111 to 120 of about 175,826 (264)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Growth hormone-releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice. [PDF]

Proc Natl Acad Sci U S A, 2023
Condor Capcha JM, Kamiar A, Robleto E, Saad AG, Cui T, Wong A, Villano J, Zhong W, Pekosz A, Medina E, Cai R, Sha W, Ranek MJ, Webster KA, Schally AV, Jackson RM, Shehadeh LA.   +16 more
europepmc   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

Advanced Science, EarlyView.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina, Kanghwan Kim, Wesley Charles Smith, Keuntae Kim, Shinwoo Lee, Jiwan Woo, Il‐Joo Cho   +6 more
wiley   +1 more source

Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice. [PDF]

Front Cardiovasc Med, 2023
Ren HL, Cai R, Xue R, Zhang Y, Xu Q, Zhang X, Cai R, Sha W, Schally AV, Zhou MS.   +9 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Growth hormone-releasing hormone in retinal disorders and uveitis: an updated review. [PDF]

Int J Ophthalmol
Yi SL, Huang YQ.
europepmc   +1 more source

Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review. [PDF]

Front Endocrinol (Lausanne), 2022
Zendran I, Gut G, Kałużny M, Zawadzka K, Bolanowski M.   +4 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Growth hormone-releasing hormone attenuates amyloid deposition and neuroinflammation in Alzheimer's disease models. [PDF]

Cell Death Dis
Pedrolli F, Morello G, Gesmundo I, Banfi D, Ferro A, Wangpaichitr M, Sha W, Tamagno E, Schally AV, Guglielmotto M, Granata R.   +10 more
europepmc   +1 more source

Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice. [PDF]

Proc Natl Acad Sci U S A, 2023
Boido M, Gesmundo I, Caretto A, Pedrolli F, Schellino R, Leone S, Cai R, Sha W, Ghigo E, Schally AV, Vercelli A, Granata R.   +11 more
europepmc   +1 more source