Results 91 to 100 of about 5,646,776 (202)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus.

PLoS ONE, 2010
BackgroundGhrelin targets the arcuate nucleus, from where growth hormone releasing hormone (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains neuropeptide Y (NPY) neurons which play a master role in the effect of ghrelin on ...
Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry   +12 more
doaj   +1 more source

Growth Hormone-Releasing Hormone Antagonists Inhibit Growth of Human Ovarian Cancer

, 2011
Epithelial ovarian carcinoma is the leading cause of cancer-related deaths among women with gynecologic malignancies. Antagonists of the growth hormone-releasing hormone (GHRH) have been shown to inhibit growth of various cancers through endocrine ...
A. Papadia, Rick, F, Szalontay, L, Buchholz, S, L. Szalontay, G. Halmos, Papadia, A, F. Rick, Lucci, J. A, M. Zarandi, Bellyei, S, A. Schally, S. Bellyei, S Seitz, J. Lucci, Zarandi, M, S. Buchholz, Halmos, G, Varga, J. L, Treszl, A, A. Treszl, Schally, A. V, Seitz, S, J. Varga   +23 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Growth Hormone Deficiency in the Transition Period

Endocrinology Research and Practice, 2019
The importance of continuing growth hormone therapy in the transition and adulthood periods must be studied in adolescents with growth hormone deficiency with childhood onset.
Doğuş VURALLI
doaj   +1 more source

The oncogenic potential of growth hormone.

, 2006
A growing body of recent literature indicates that in addition to an essential role in growth and development, growth hormone may also play a more sinister role in oncogenic transformation and neoplastic progression.
Starling Emerald, B, Mertani, HC, Lobie, Peter E, Perry, Jo K, Mertani, Hichem, Emerald, B Starling, Lobie, PE, Perry, JK   +7 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

ENHANCED LEUKOPOIESIS IN GHRELIN TREATED MYELOSUPPRESSED RATS

Pakistan Armed Forces Medical Journal, 2017
Objective: To determine the role of ghrelin in stimulating leukopoiesis of myelosuppressed rats by stimulating growth hormone release. Study Design: Randomized controlled trial.
Tehreem Aftab, Sadia Ahsin, Saadat Ali Khan, Ehtisham Khyzer   +3 more
doaj   +2 more sources

Treatment of growth hormone deficiency in adults

, 2009
BACKGROUND: The Growth Hormone Research Society held a Consensus Workshop in Sydney, Australia, in March 2007 to review advances in the management of growth hormone (GH) deficiency in adults and to update consensus recommendations.
Johannsson, Gudmundur,
core   +1 more source