Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection [PDF]
Neural Regeneration Research, 2022 Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen +3 more
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Growth hormone-releasing hormone, growth hormone, and neuroendocrine tumors [PDF]
Journal of Clinical & Translational EndocrinologyNeuroendocrine tumors (NETs) are known to produce growth hormone (GH) and growth hormone-releasing hormone (GHRH) leading to acromegaly. Ectopic production of these hormones can lead to ectopic acromegaly which is very rare.
Maham Shahid, Christian A. Koch
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Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review [PDF]
Frontiers in Endocrinology, 2022 IntroductionEctopic acromegaly is a rare condition caused most frequently by growth hormone releasing hormone (GHRH) secretion from neuroendocrine tumors.
Iga Zendran +4 more
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Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation [PDF]
Nature Communications, 2023 Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune and inflammatory diseases. Previously growth hormone releasing hormone receptor (GHRH-R) deficient mice have been reported to be less susceptible to the ...
Lin Du +11 more
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VMN growth hormone-releasing hormone receptor regulation of counterregulatory transmission [PDF]
Academia BiologyVentromedial hypothalamic nucleus (VMN) growth hormone-releasing hormone (Ghrh) neurotransmission governs counterregulatory hormone release.
Subash Sapkota +4 more
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Growth hormone-releasing hormone in retinal disorders and uveitis: an updated review [PDF]
International Journal of OphthalmologyGrowth hormone-releasing hormone (GHRH) is a hypothalamic releasing hormone that plays a crucial physiological role in regulating the synthesis and release of anterior pituitary hormones.
Sha-Lin Yi, Yu-Qiang Huang
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Growth hormone-releasing hormone attenuates amyloid deposition and neuroinflammation in Alzheimer’s disease models [PDF]
Cell Death and DiseaseAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau hyperphosphorylation, neuroinflammation, and synaptic loss.
Francesca Pedrolli +10 more
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Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice [PDF]
Frontiers in Cardiovascular Medicine, 2023 IntroductionVascular calcification (VC) is an independent risk factor for cardiovascular diseases. VC increases mortality of all-causes. VC is one of most common cardiovascular complications in type II diabetes.
Hao-Lin Ren +18 more
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Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs [PDF]
Frontiers in Veterinary ScienceAging leads to increased disease susceptibility and weakened immunity, a condition known as immunosenescence. The growth hormone-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis plays a key role in both somatic ...
Min-Ok Ryu +9 more
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Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury [PDF]
EndocrinesGHRH regulates the secretion of GH from the anterior pituitary gland, previously associated with cancer progression and inflammation. An emerging body of evidence suggests that GHRHAnt support endothelial barrier function, but the mechanisms mediating ...
Saikat Fakir, Nektarios Barabutis
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