Neuroprotective actions of ghrelin and growth hormone secretagogues [PDF]
Frontiers in Molecular Neuroscience, 2011 The brain incorporates and coordinates information based on the hormonal environment, receiving information from peripheral tissues through the circulation.
Laura M. Frago +14 more
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Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy [PDF]
Frontiers in Immunology, 2023 IntroductionGrowth hormone secretagogues (GHSs) exert multiple actions, being able to activate GHS-receptor 1a, control inflammation and metabolism, to enhance GH/insulin-like growth factor-1 (IGF-1)-mediated myogenesis, and to inhibit angiotensin ...
Brigida Boccanegra +20 more
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The synthesis of a small library of prospective growth hormone secretagogues [PDF]
Journal of the Serbian Chemical Society, 1999 Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
Pejović Vojislav +2 more
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Growth hormone secretagogues: history, mechanism of action, and clinical development
JCSM Rapid Communications, 2020 Growth hormone secretagogues (GHSs) are a generic term to describe compounds that increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the growth
Junichi Ishida +5 more
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Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
A.-M.J. Lengyel
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The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration [PDF]
Frontiers in EndocrinologyPerformance-enhancing drugs (PEDs) marketed as “research compounds” include unregulated peptides intended to modulate the growth hormone–insulin-like growth factor-1 (GH–IGF-1) axis.
Aleksander Dominikowski +5 more
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Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. [PDF]
PLoS ONE, 2012 BackgroundIschemic heart disease is a leading cause of mortality. To study this disease, ischemia/reperfusion (I/R) models are widely used to mimic the process of transient blockage and subsequent recovery of cardiac coronary blood supply.
Yi Ma +4 more
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Editorial: Inflammation in muscular dystrophies: mediators, mechanisms, and therapeutics [PDF]
Frontiers in ImmunologyChiara Villa +3 more
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Endocrinology Research and Practice, 2022 Growth hormone secretagogues are synthetic peptidyl and non- peptidyl molecules that possess growth hormone releasing activity. Ghrelin is an endogenous natural ligand for the growth hormone secretagogue receptor that has recently been isolated from the ...
Serdar Güler +2 more
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Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus. [PDF]
PLoS ONE, 2013 In models of status epilepticus ghrelin displays neuroprotective effects mediated by the growth hormone secretagogue-receptor 1a (GHS-R1a). This activity may be explained by anticonvulsant properties that, however, are controversial.
Chiara Lucchi +7 more
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