Neuroprotective actions of ghrelin and growth hormone secretagogues [PDF]
Frontiers in Molecular Neuroscience, 2011 The brain incorporates and coordinates information based on the hormonal environment, receiving information from peripheral tissues through the circulation.
Laura M. Frago +14 more
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Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy [PDF]
Frontiers in Immunology, 2023 IntroductionGrowth hormone secretagogues (GHSs) exert multiple actions, being able to activate GHS-receptor 1a, control inflammation and metabolism, to enhance GH/insulin-like growth factor-1 (IGF-1)-mediated myogenesis, and to inhibit angiotensin ...
Brigida Boccanegra +20 more
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Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
A.-M.J. Lengyel
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Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. [PDF]
PLoS ONE, 2012 BackgroundIschemic heart disease is a leading cause of mortality. To study this disease, ischemia/reperfusion (I/R) models are widely used to mimic the process of transient blockage and subsequent recovery of cardiac coronary blood supply.
Yi Ma +4 more
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Growth hormone secretagogues: history, mechanism of action, and clinical development
JCSM Rapid Communications, 2020 Growth hormone secretagogues (GHSs) are a generic term to describe compounds that increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the growth
Junichi Ishida +5 more
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Cisplatin‐Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions [PDF]
Journal of Cachexia, Sarcopenia and MusclePlatinum‐based chemotherapeutics, particularly cisplatin, are crucial in the treatment of various malignancies due to their strong antitumor effects.
Ko‐Chieh Huang +3 more
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Editorial: Inflammation in muscular dystrophies: mediators, mechanisms, and therapeutics [PDF]
Frontiers in ImmunologyChiara Villa +3 more
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The synthesis of a small library of prospective growth hormone secretagogues [PDF]
Journal of the Serbian Chemical Society, 1999 Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
Pejović Vojislav +2 more
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Endocrinology Research and Practice, 2022 Growth hormone secretagogues are synthetic peptidyl and non- peptidyl molecules that possess growth hormone releasing activity. Ghrelin is an endogenous natural ligand for the growth hormone secretagogue receptor that has recently been isolated from the ...
Serdar Güler +2 more
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Dynamin Is Functionally Coupled to Insulin Granule Exocytosis [PDF]
, 2007 The insulin granule integral membrane protein marker phogrin-green fluorescent protein was co-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane translocation following glucose stimulation.
Gaisano, HY +7 more
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