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The Journal of Poultry Science, 2006 Growth hormone secretagogues (GHS), including ghrelin, are known to stimulate feeding behavior in mammals. In contrast, intracerebroventricular (ICV) injection of rat or chicken ghrelin, strongly inhibits food intake in chicks.
Md. Sakirul Islam Khan +8 more
doaj +1 more source
Development of Growth Hormone Secretagogues [PDF]
Endocrine Reviews, 2005 The GH secretagogues (GHS) were developed by reverse pharmacology. The objective was to develop small molecules with pharmacokinetics suitable for once-daily oral administration that would rejuvenate the GH/IGF-I axis. Neither the receptor nor the ligand that controlled pulse amplitude of hormone release was known; therefore, identification of lead ...
openaire +2 more sources
Subpopulations of Chicken Somatotropes with Differing Intracellular Calcium Concentrations Responses to Secretagogues [PDF]
, 2008 Multiple secretagogues stimulate the release of growth hormone (GH). The present studies examined the ability of chicken somatotropes to respond to GH secretagogues with increased intracellular calcium concentrations ([Ca 2+ ]i ). It was hypothesized
Anderson, Lloyd +4 more
core +1 more source
, 2004 The action of a number of growth hormone secretagogues (GHS) on growth hormone (GH) secretion and gene expression was studied in a primary culture of pituitary cells isolated from the black seabream Acanthopagrus schlegeli.
Fung, C. K. +4 more
core +2 more sources
Ghrelin and growth hormone secretagogues (GHS): modulation of growth hormone secretion and therapeutic applications [PDF]
, 2008 Growth hormone-releasing hormone (GHRH) and somatostatin modulate growth hormone (GH) secretion. A third mechanism was discovered in the last decade, involving the action of growth hormone secretagogues (GHS).
Sá,Larissa Bianca Paiva Cunha de +8 more
core +2 more sources
Glycine‐modified growth hormone secretagogues identified in seized doping material
, 2019 A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis.
Rasmussen, Brian Schou +6 more
core +1 more source
Biochemistry and Biophysics Reports, 2016 Background: Growth hormone secretagogues (GHS), among other factors, regulate the release of GH. The biological activity of the secretagogue peptide A233 as a promoter of growth and innate immunity in teleost fish has previously been demonstrated, but ...
Rebeca Martínez +17 more
doaj +1 more source
Growth hormone and insulin-like growth factor-1
, 2016 Human growth hormone was first isolated from human pituitary glands in 1945 and found to promote the growth of children with hypopituitarism. Since the formation of the World Anti-Doping Association, human growth hormone has appeared on the list of ...
Nicholls, A.R. +3 more
core +1 more source
Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the growth hormone research society workshop on adult growth hormone deficiency [PDF]
, 1998 Based on the increasing body of evidence that adults with GH deficiency (somatotropin deficiency) have impaired health that improves with GH replacement, many countries have already approved the use of GH for replacement therapy in adults with GH ...
Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency +1 more
core +1 more source
New therapeutic options for metabolic‐associated steatotic liver disease
British Journal of Clinical Pharmacology, EarlyView.An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley +1 more source