Results 31 to 40 of about 5,265,812 (178)

Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels

open access: yesAmerican Journal of Men's Health, 2017
Realizing the reported misuse of human growth hormone (GH), investigation of a safe alternative mechanism for increasing endogenous GH is needed. Several GH secretagogues are available, including GH-releasing peptides (GHRPs) GHRP-2 and GHRP-6, and the ...
John T. Sigalos   +6 more
doaj   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

open access: yesFood Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee   +4 more
wiley   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

open access: yesObesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye   +6 more
wiley   +1 more source

The oncogenic potential of growth hormone.

open access: yes, 2006
A growing body of recent literature indicates that in addition to an essential role in growth and development, growth hormone may also play a more sinister role in oncogenic transformation and neoplastic progression.
Starling Emerald, B   +7 more
core   +1 more source

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

open access: yesArthritis &Rheumatology, Volume 78, Issue 9, Page 1837-1849, September 2026.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan   +12 more
wiley   +1 more source

Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies

open access: yesFood Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi   +9 more
wiley   +1 more source

Ghrelin and growth hormone secretagogues (GHS): modulation of growth hormone secretion and therapeutic applications [PDF]

open access: yes, 2008
Growth hormone-releasing hormone (GHRH) and somatostatin modulate growth hormone (GH) secretion. A third mechanism was discovered in the last decade, involving the action of growth hormone secretagogues (GHS).
Sá,Larissa Bianca Paiva Cunha de   +8 more
core   +2 more sources

Neuroregulation of the Hypothalamus-Pituitary-Adrenal (HPA) Axis in Humans: Effects of GABA-, Mineralocorticoid-, and GH-Secretagogue-Receptor Modulation

open access: yesThe Scientific World Journal, 2006
The hypothalamus-pituitary-adrenal (HPA) axis exerts a variety of effects at both the central and peripheral level. Its activity is mainly regulated by CRH, AVP, and the glucocorticoid-mediated feedback action.
Roberta Giordano   +7 more
doaj   +1 more source

Periodontitis and Mechanical Forces Modulate Ghrelin Receptor in Periodontal Tissues

open access: yesAPMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Ghrelin signaling, mediated by the growth hormone secretagogue receptor (GHS‐R1a), has emerged as an important regulator of inflammation and bone metabolism. This study investigated GHS‐R1a regulation in periodontal tissues exposed to experimental periodontitis (EP), orthodontic tooth movement (OTM), or both. Human periodontal fibroblasts were
Andressa Vilas Boas Nogueira   +10 more
wiley   +1 more source

Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma. [PDF]

open access: yes, 2013
Includes abstract.Includes bibliographical references.Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low.
Boris Krivochiev, Krivochiev, Boris
core   +1 more source

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