Results 51 to 60 of about 5,558,251 (188)

Acute high‐protein feeding induces hepatic amino acid accumulation in diabetic male mice prior to transcriptional adaptation

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Glucagon plays a pivotal role in hepatic amino acid metabolism; acute high‐protein diet feeding and diabetic condition both induce enhanced glucagon secretion. However, it remains unknown whether these two conditions alter hepatic amino acid metabolism through the same or different pathways.
Hiroaki Sumioki, Eisuke Tomatsu, Yusuke Seino, Shihomi Hidaka, Shinji Ueno, Sayumi Kanie, Koki Nishida, Takuya Haraguchi, Naoya Murao, Haruki Fujisawa, Takeshi Takayanagi, Yoshihisa Sugimura, Yoshitaka Hayashi, Atsushi Suzuki   +13 more
wiley   +1 more source

Genetic variation of metabolite and hormone concentration in UK Holstein-Friesian calves and the genetic relationship with economically important traits [PDF]

, 2009
The decline of dairy cattle fertility worldwide remains a major concern, with conception rates to first service commonly below 40%. The length and severity of negative energy balance postpartum are unfavorably correlated with fertility, suggesting that ...
Woolliams, J A, Royal, M D, Flint, A P F, Hayhurst, C, Løvendahl, P, P. Løvendahl, M.D. Royal, A.P.F. Flint, J.A. Woolliams, C. Hayhurst   +9 more
core   +1 more source

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +1 more source

JMV2894, a novel growth hormone secretagogue, accelerates body mass recovery in an experimental model of cachexia

, 2017
Oncologic patients subjected to chemotherapy frequently present aphagia, malnutrition, and cachexia. The purpose of this study was to investigate whether selected growth hormone secretagogues including hexarelin, JMV2894 and JMV2951 could antagonize body
Torsello, Antonio, Martinez, Jean, Fehrentz, Jean-Alain, Fehrentz, Jean Alain, Locatelli, Vittorio, Biagini, Giuseppe, Omeljaniuk, Robert, Bresciani, Elena, Ben Haj Salah, Khoubaib, Molteni, Laura, LIANTONIO, ANTONELLA, Omeljaniuk, Robert J., Rizzi, Laura, Ravelli, Monica   +13 more
core   +1 more source

Growth Hormone and Metabolic Homeostasis

European Medical Journal Diabetes, 2018
Pituitary growth hormone (GH) is a peptide hormone predominantly secreted by somatotrophs in the anterior pituitary under the tight control of the hypothalamic–pituitary axis and GH secretagogues.
Rajkishor Nishad, Dhanunjay Mukhi, Dhanunjay Mukhi, Ram K. Menon   +3 more
doaj  

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Uso di agonisti e antagonisti dei recettori per i growth hormone secretagogues per la prevenzione e il trattamento di convulsioni ed epilessia [PDF]

, 2010
L’invenzione riguarda l’uso di agonisti e antagonisti dei recettori per i Growth Hormone Secretagogues utili nella prevenzione e nel trattamento di convulsioni, ad esempio acute, ricorrenti, a grappolo, associate o non associate ad epilessia, e di stati ...
BIAGINI, Giuseppe
core  

Decrease in adiponectin levels correlates to growth response in growth hormone-treated children

, 2009
BACKGROUND/AIMS: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity.
Carlsson, LMS, Swedish, Study Group for Growth Hormone Treatment, Andersson, B, Albertsson-Wikland, K, Carlsson, B, Bjarnason, R   +5 more
core   +1 more source

Alcohol Exposure Alters the Ghrelin System: In Vitro Mechanistic Insights Into Impaired Glucose Sensing and Enhanced Ghrelin Secretion

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
Chronic ethanol exposure increases ghrelin production by impairing glucose sensing in ghrelin‐secreting cells. Ethanol elevates ghrelin and ghrelin O‐acyltransferase expression, blunts glucose‐mediated suppression, and synergizes with fatty acids to enhance secretion.
Sundararajan Mahalingam, Ramesh Bellamkonda, Kusum K. Kharbanda, Ojeshvi Ethiraj, Carol A. Casey, Karuna Rasineni   +5 more
wiley   +1 more source

Growth hormone secretagogues: history, mechanism of action and clinical development

, 2019
Growth hormone secretagogues (GHSs) are a generic term to describe compounds which increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the ...
Ishida, Junichi, Springer, Jochen, Haehling, Stephan von, Saitoh, Masakazu, Ebner, Nicole, Anker, Stefan D.   +5 more
core