Results 51 to 60 of about 5,265,812 (178)

TBC1D4‐Related Monogenic Diabetes: Molecular Mechanisms, Clinical Recognition, and Therapeutic Implications

Journal of Diabetes, Volume 18, Issue 8, August 2026.
TBC1D4‐related monogenic diabetes is characterized by defective AS160‐mediated GLUT4 trafficking, skeletal muscle insulin resistance, and predominant postprandial hyperglycemia. Clinical recognition relies on atypical young‐onset diabetes with marked insulin resistance, followed by genetic confirmation and individualized management.
Wenjing Wang, Lidan Ma, Bingzi Dong, Peihan Gao, Xiaofang Sun   +4 more
wiley   +1 more source

Effects of growth hormone and its secretagogues on bone

, 2001
The growth hormone (GH)/insulin-like growth factor-1 axis is not only of importance for linear body growth during childhood, but it is also one of the major determinants of adult bone mass. Studies show that GH treatment increases bone mass in rodents as
Ohlsson, Claes,, Jansson, John-Olov,, Svensson, Johan,, Lall, S, Ahnfelt-Rønne, I, Dickson, Suzanne L.,, Bengtsson, Bengt-Åke,, Rømer, J   +7 more
core   +1 more source

Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8‐Week Crossover Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5779-5786, July 2026.
ABSTRACT Aims To evaluate the effects of premeal versus postmeal metformin administration on postmeal glycemic control in individuals with type 2 diabetes mellitus receiving metformin monotherapy. Methods All participants were randomly assigned to receive immediate‐release metformin either 30–60 min before or immediately after meal for 4 weeks, and ...
Issaree Rattarasarn, Chatvara Areevut, Khaimook Prachakeserane, La‐Or Chailurkit, Chutintorn Sriphrapradang, Chatchalit Rattarasarn   +5 more
wiley   +1 more source

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, Volume 56, Issue 7, Page 1126-1133, July 2026.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Growth Hormone and Metabolic Homeostasis

European Medical Journal Diabetes, 2018
Pituitary growth hormone (GH) is a peptide hormone predominantly secreted by somatotrophs in the anterior pituitary under the tight control of the hypothalamic–pituitary axis and GH secretagogues.
Rajkishor Nishad, Dhanunjay Mukhi, Dhanunjay Mukhi, Ram K. Menon   +3 more
doaj  

Laparoscopic resection of small bowel neuroendocrine tumors: A long‐term survival analysis

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Small bowel neuroendocrine tumors (SBNET) are rare neoplasms that often present insidiously and may be associated with mesenteric fibrosis and advanced disease at diagnosis. While open surgery has traditionally been the standard of care, the role of laparoscopic resection in patients with complex SBNET remains under evaluation.
Michal Perets, Ofra Carmel, Anoushka Adler, Nir Horesh, Simona Grozinsky‐Glasberg, Petachia Reissman, Michael R. Freund   +6 more
wiley   +1 more source

Novel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia is a debilitating syndrome marked by involuntary weight loss resulting from reduced food intake and intricate metabolic reprogramming. Despite its high prevalence, cancer cachexia remains undertreated, with a lack of effective and approved pharmacotherapies.
J. E. Hunt, C. Lund, B. Chen, A. R. Diaz, O. Dmytriyeva, J. Marcotorchino, K. Löbner, K. Mörl, N. R. Andersen, Z. K. J. Ogueboule, E. Frank, J. Stöhr, D. Meseguer, V. Panajotova, J. Roux, C. Clemmensen, L. Sylow, M. Schneeberger, A. G. Beck‐Sickinger, S. L. Pedersen, K. Fosgerau   +20 more
wiley   +1 more source

Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Pregnancy and lactation trigger many metabolic adaptations, including increased food intake to support the energy demands of the growing foetus and then to provide nutrition through milk production after birth. Ghrelin, an orexigenic hormone, activates agouti related peptide (AgRP) neurons in the arcuate nucleus to promote food intake.
C. L. Murrell, M. R. Perkinson, Z. B. Andrews, D. R. Grattan, S. R. Ladyman   +4 more
wiley   +1 more source

Analogs of Growth Hormone-Releasing Hormone: Endocrine and Oncological Studies

, 1998
Andrew V. Schally, Magdolna Kovacs, Katalin Toth, and Ana Maria Comaru-Schally Tulane University School of Medicine and Veterans Affairs Medical Center, New Orleans, LouisianaI.
Schally, Andrew V., Kovacs, Magdolna, Comaru-Schally, Ana Maria, Toth, Katalin   +3 more
core   +1 more source

Growth cartilage expression of growth hormone/insulin-like growth factor I axis in spontaneous and growth hormone induced catch-up growth [PDF]

, 2012
Introduction: Catch-up growth following the cessation of a growth inhibiting cause occurs in humans and animals. Although its underlying regulatory mechanisms are not well understood, current hypothesis confer an increasing importance to local factors ...
Santos Rodríguez, Fernando, Caldas-Afonso, A, Loredo, V, Caldas-Afonso, Alberto, Santos, F, Tiago Henriques-Coelho, Coelho, Tiago Alexandre Henriques, Brito, Iva, Gil-Peña, H, Loredo López, Vanessa, Molinos, I, Gil Peña, Helena, Brito, I, Molinos Norniella, Inés   +13 more
core   +1 more source