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Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus?

Clinical Interventions in Aging, 2008
Elizabeth C Hersch, George R MerriamVA Puget Sound Health Care System and University of Washington School of Medicine, Tacoma and Seattle, Washington USAAbstract: Although growth hormone (GH) is primarily associated with linear growth in childhood, it ...
Elizabeth C Hersch, George R Merriam
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Editorial Foreword: Comments on "Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging" || FREE PAPER ||

Clinical Interventions in Aging, 2008
Richard F WalkerInternational Society for Applied Research in Aging (SARA)This issue of Clinical Interventions in Aging contains a quite interesting and informative article about a topic that is popular and also controversial among practitioners of age ...
Richard F Walker
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Growth Hormone-Releasing Hormone in Diabetes [PDF]

Frontiers in Endocrinology, 2016
Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland.
Leonid Evsey Fridlyand, Natalia A Tamarina, Andrew V Schally, Louis H Philipson   +3 more
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Growth Hormone Secretagogues and the Regulation of Calcium Signaling in Muscle. [PDF]

Int J Mol Sci, 2019
Growth hormone secretagogues (GHS) are a family of synthetic molecules, first discovered in the late 1970s for their ability to stimulate growth hormone (GH) release. Many effects of GHS are mediated by binding to GHS-R1a, the receptor for the endogenous
Bresciani E, Rizzi L, Coco S, Molteni L, Meanti R, Locatelli V, Torsello A.   +6 more
europepmc   +2 more sources

Biologic Activities of Growth Hormone Secretagogues in Humans

Endocrine, 2001
Growth hormone secretagogues (GHSs) are synthetic peptidyl and nonpeptidyl molecules with strong, dose-dependent, and reproducible growth hormone (GH)-releasing activity even after oral administration. GHSs release GH via actions on specific receptors (GHS-R) at the pituitary and, mainly, at the hypothalamic levels.
GHIGO, Ezio, ARVAT, Emanuela, GIORDANO, Roberta, BROGLIO, Fabio, GIANOTTI L, MACCARIO, Mauro, BISI, Gianni, GRAZIANI A, PAPOTTI, Mauro Giulio, MUCCIOLI, Giampiero, DEGHENGHI R, CAMANNI, Franco   +11 more
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The Safety and Efficacy of Growth Hormone Secretagogues. [PDF]

Sex Med Rev, 2018
Growth hormone (GH) increases lean body mass, decreases fat mass, increases exercise tolerance and maximum oxygen uptake, enhances muscle strength, and improves linear growth. Long-term studies of GH administration offer conflicting results on its safety, which has led to strict Food and Drug Administration criteria for GH use.
Sigalos JT, Pastuszak AW.
europepmc   +4 more sources

Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia. [PDF]

Ann N Y Acad Sci
Glucagon, a counterregulatory hormone released from pancreatic α‐cells, maintains glucose homeostasis by acting as a protective barrier against hypoglycemia and an amplifier of insulin release when glucose levels rise with feeding. In the body, glucagon secretion is regulated by circulating glucose levels, with elevations in amino acids and via other ...
Fatehi S, Rocheleau JV, Riddell MC.
europepmc   +2 more sources

Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues like macimorelin have potential to mitigate these effects.
Megan Herodes, Lindsey J. Anderson, Samuel Shober, Ellen A. Schur, Solomon A. Graf, Nicola Ammer, Ramiro Salas, Marco Marcelli, Jose M. Garcia   +8 more
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The growth hormone secretagogue receptor

Growth Hormone & IGF Research, 1999
The specific human growth hormone (GH) secretagogue receptor (type la) was cloned in 1996 using the nonpeptide GH secretagogue MK-0677 as a ligand. 1,2 It belongs to the G-protein coupled seven transmembrane domain receptor family, but does not show close homology with any of the known subgroups of receptors, though its sequence is conserved between ...
KORBONITS M., CICCARELLI E., GHIGO, Ezio, GROSSMAN AB   +3 more
openaire   +3 more sources

Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients. [PDF]

PLoS ONE, 2009
Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and GH secretagogues reverse age-related changes in ...
Gabriel Morrhaye, Hamid Kermani, Jean-Jacques Legros, Frederic Baron, Yves Beguin, Michel Moutschen, Remi Cheynier, Henri J Martens, Vincent Geenen   +8 more
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