Development of Growth Hormone Secretagogues [PDF]
Endocrine Reviews, 2005 The GH secretagogues (GHS) were developed by reverse pharmacology. The objective was to develop small molecules with pharmacokinetics suitable for once-daily oral administration that would rejuvenate the GH/IGF-I axis. Neither the receptor nor the ligand that controlled pulse amplitude of hormone release was known; therefore, identification of lead ...
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Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia. [PDF]
J Cachexia Sarcopenia Muscle, 2017 Conte E +21 more
europepmc +2 more sources
Calibrated Integrated Backscatter Is Associated With Increased Left Ventricular Concentricity and Left Atrial Stiffness in Resistance Trained Individuals Using Anabolic-Androgenic Steroids. [PDF]
EchocardiographyThis study evaluates calibrated integrated backscatter (ciB) for myocardial tissue characterization in 141 resistance‐trained participants (95 AAS users, 46 non‐users). Using echocardiography, ciB was measured from the parasternal long axis orientation. Results show current AAS users have significantly higher ciB than non‐users (–19.54 vs.
Place F +10 more
europepmc +2 more sources
Growth Hormone-Releasing Peptides: Investigation of Their Secondary Structure, Thermal Stability, and Model Membrane Interactions. [PDF]
ChiralityEight growth hormone–releasing peptides were analyzed by electronic circular dichroism spectroscopy, including evaluation of their thermal stability and interactions with model membranes. In the selected case, occurring interactions were successfully described by the density functional theory calculations, revealing how model membranes affected ...
Králík F +4 more
europepmc +2 more sources
Ghrelin regulates proliferation and differentiation of osteoblastic cells [PDF]
, 2005 It has previously been reported that growth hormone secretagogues (GHS) may have a role in the regulation of bone metabolism in animals and humans.
COCCHI, Daniela +7 more
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Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus. [PDF]
PLoS ONE, 2013 In models of status epilepticus ghrelin displays neuroprotective effects mediated by the growth hormone secretagogue-receptor 1a (GHS-R1a). This activity may be explained by anticonvulsant properties that, however, are controversial.
Chiara Lucchi +7 more
doaj +1 more source
Dos peptídeos liberadores do hormônio de crescimento (HC) à ghrelina: descoberta de novos moduladores da secreção de HC [PDF]
, 2006 Growth hormone (GH)-releasing hormone and somatostatin modulate GH secretion. A third mechanism has been discovered in the last decade, involving the action of GH secretagogues.
Lengyel, Ana Maria Judith
core +4 more sources
Identification of the growth hormone-releasing hormone analogue [Pro1, Val14]-hGHRH with an incomplete C-term amidation in a confiscated product [PDF]
, 2014 A
Deventer, Koen +2 more
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Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues like macimorelin have potential to mitigate these effects.
Megan Herodes +8 more
doaj +1 more source
Influence of glucocorticoids on the somatotrophic axis [PDF]
, 2003 GH secretion is modulated by a complex interplay between two hypothalamic factors, GHRH (growth hormone-releasing hormone) and somatostatin (SRIF). More recently, a third physiological mechanism mediated by GHS (growth hormone secretagogues) and its ...
Correa-Silva, Silvia Regina +1 more
core +3 more sources