Growth hormone secretagogues: history, mechanism of action, and clinical development
JCSM Rapid Communications, 2020 Growth hormone secretagogues (GHSs) are a generic term to describe compounds that increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the growth
Junichi Ishida +5 more
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Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
A.-M.J. Lengyel
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Clinical Interventions in Aging, 2008 Richard F WalkerInternational Society for Applied Research in Aging (SARA)This issue of Clinical Interventions in Aging contains a quite interesting and informative article about a topic that is popular and also controversial among practitioners of age ...
Richard F Walker
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Intra-Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia. [PDF]
Ann N Y Acad SciGlucagon, a counterregulatory hormone released from pancreatic α‐cells, maintains glucose homeostasis by acting as a protective barrier against hypoglycemia and an amplifier of insulin release when glucose levels rise with feeding. In the body, glucagon secretion is regulated by circulating glucose levels, with elevations in amino acids and via other ...
Fatehi S, Rocheleau JV, Riddell MC.
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Editorial: Inflammation in muscular dystrophies: mediators, mechanisms, and therapeutics [PDF]
Frontiers in ImmunologyChiara Villa +3 more
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Endocrinology Research and Practice, 2022 Growth hormone secretagogues are synthetic peptidyl and non- peptidyl molecules that possess growth hormone releasing activity. Ghrelin is an endogenous natural ligand for the growth hormone secretagogue receptor that has recently been isolated from the ...
Serdar Güler +2 more
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Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus. [PDF]
PLoS ONE, 2013 In models of status epilepticus ghrelin displays neuroprotective effects mediated by the growth hormone secretagogue-receptor 1a (GHS-R1a). This activity may be explained by anticonvulsant properties that, however, are controversial.
Chiara Lucchi +7 more
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Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Cancer cachexia is associated with reduced body weight, appetite and quality of life (QOL) with no approved treatments. Growth hormone secretagogues like macimorelin have potential to mitigate these effects.
Megan Herodes +8 more
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The growth hormone secretagogue receptor
Growth Hormone & IGF Research, 1999 The specific human growth hormone (GH) secretagogue receptor (type la) was cloned in 1996 using the nonpeptide GH secretagogue MK-0677 as a ligand. 1,2 It belongs to the G-protein coupled seven transmembrane domain receptor family, but does not show close homology with any of the known subgroups of receptors, though its sequence is conserved between ...
KORBONITS M. +3 more
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Genetic variation of metabolite and hormone concentration in UK Holstein-Friesian calves and the genetic relationship with economically important traits [PDF]
, 2009 The decline of dairy cattle fertility worldwide remains a major concern, with conception rates to first service commonly below 40%. The length and severity of negative energy balance postpartum are unfavorably correlated with fertility, suggesting that ...
Woolliams, J A +4 more
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