Clinics, 2012 OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormonereleasing hormone receptors.
Cibele N. Peroni +7 more
doaj +1 more source
Influence of glucocorticoids on the somatotrophic axis [PDF]
, 2003 GH secretion is modulated by a complex interplay between two hypothalamic factors, GHRH (growth hormone-releasing hormone) and somatostatin (SRIF). More recently, a third physiological mechanism mediated by GHS (growth hormone secretagogues) and its ...
Correa-Silva, Silvia Regina +1 more
core +3 more sources
Advanced bone age as an indicator facilitates the diagnosis of precocious puberty
Jornal de Pediatria (Versão em Português), 2018 Objective: Diagnosis of central precocious puberty has always been challenging in clinicalpractice. As an important method in the diagnosis of central precocious puberty, luteinizinghormone‐releasing hormone stimulation test is complex and time‐consuming.
Yue‐Qin Xu, Gui‐Mei Li, Yan Li
doaj +1 more source
Effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys with idiopathic central precocious puberty [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose There are few reports on the therapeutic effects of gonadotropin-releasing hormone agonists in boys with central precocious puberty, and studies reported in Korea are very rare.
Ah Young Cho +3 more
doaj +1 more source
Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]
, 2016 Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E. +6 more
core +1 more source
Receptor oligomerization: from early evidence to current understanding in class B GPCRs [PDF]
, 2013 Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization.
Chow, BKC, Lee, TO, Ng, SYL
core +1 more source
Structural basis for activation of the growth hormone-releasing hormone receptor
Nature Communications, 2020 Growth hormone-releasing hormone (GHRH) controls metabolism and tissue growth through binding to the cognate receptor (GHRHR). Here authors report the structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein which reveals
Fulai Zhou +21 more
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Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]
, 2018 Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
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Journal of Clinical and Translational Science, 2023 Tesamorelin, a synthetic growth hormone-releasing hormone, is indicated for the reduction of visceral adipose tissue (VAT) in people with HIV. Here, we performed a post hoc analysis of participants receiving tesamorelin for 26 weeks in a phase III ...
Farah Rahman +6 more
doaj +1 more source
The decrease in growth hormone (GH) response after repeated stimulation with GH-Releasing hormone is partly caused by an elevation of somatostatin tonus. [PDF]
, 1996 Repeated injection of GHRH leads to a decrease in the GH response in normal subjects. Arginine (Arg) stimulates GH secretion by suppression of hypothalamic somatostatin.
Mehltretter, Gerhard +5 more
core +1 more source