Results 41 to 50 of about 513,294 (388)
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The current therapeutic approaches to the treatment of benign prostatic hyperplasia (BPH) do not take into consideration that inflammation is an important factor in the pathogenesis of this disease.
Petra Popovics +4 more
semanticscholar +1 more source
Unbinding of Retinoic Acid from its Receptor Studied by Steered Molecular Dynamics [PDF]
Biophysical Journal 76, 188 (1999), 1999 Retinoic acid receptor (RAR) is a ligand-dependent transcription factor that regulates the expression of genes involved in cell growth, differentiation, and development. Binding of the retinoic acid hormone to RAR is accompanied by conformational changes in the protein which induce transactivation or transrepression of the target genes.
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Gastric cancer (GC) is a leading and lethal malignancy in the world. Unfortunately, therapeutics targeting GC lag behind those of many other cancers, and the effective treatment options are limited.
J. Gan +17 more
semanticscholar +1 more source
High Sensitivity Mass Spectrometric Quantification of Serum Growth Hormone by Amphiphilic Peptide Conjugation [PDF]
J Mass Spectrom 47(2012)1554, 2012 Amphiphilic peptide conjugation affords a significant increase in sensitivity with protein quantification by electrospray-ionization mass spectrometry. This has been demonstrated here for human growth hormone in serum using N-(3-iodopropyl)-N,N,N-dimethyloctylammonium iodide (IPDOA-iodide) as derivatizing reagent.
arxiv +1 more source
, 1996 A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats.
Herder, W.W. (Wouter) de +3 more
core +1 more source
Label-free assaying of testosterone and growth hormones in blood using surface-enhanced raman spectroscopy [PDF]
arXiv, 2023 This work reports the potential use of surface enhanced Raman spectroscopy (SERS) in rapid, label-free assaying of testosterone (TE) and growth hormone (GH) in whole blood. Biomarker SERS spectral bands from the two hormones (TE and GH) in intentionally spiked water for injection and in male Sprague-Dawley (SD) rat blood are reported.
arxiv
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Improved therapeutic strategies for transplantation of pancreatic islet cells to selected patients with type-1 diabetes are urgently needed.
Xianyang Zhang +12 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance Therapeutic options for recurrent castration-resistant prostate cancer (CRPC) are limited and more effective treatment regimens are needed. Antagonists of growth hormone-releasing hormone (GHRH) inhibit growth of experimental models of human
Cale D. Fahrenholtz +7 more
semanticscholar +1 more source
Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks
The Journal of Poultry Science, 2016 Growth hormone-releasing hormone (GHRH), a stimulator of growth hormone (GH) secretion, is known to have several physiological roles such as the regulation of feeding behavior in mammals. Recently, we have reported that central injection of chicken GHRH
Tetsuya Tachibana +5 more
doaj +1 more source
Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent [PDF]
arXiv, 2023 Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production.
arxiv