Results 71 to 80 of about 513,294 (388)

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, EarlyView.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis [PDF]

International Journal of Fertility and Sterility, 2013
Background: The present study aims to explore the significance of the expression of growth hormone-releasing hormone (GHRH) and its receptor splice variant 1 (GHRHSV1) in endometriosis (EM).
Qiming Wang, Yueyue Wang, Xianhu Fu, Yong Huang   +3 more
doaj  

Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis [PDF]

arXiv, 2023
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant data (IPD) from randomised controlled trials (RCTs) are unavailable. Methods: A Bayesian network meta-regression model, combining aggregate data (AD) from RCTs and IPD ...
arxiv  

Telarca precoce: identificação de dados clínicos e laboratoriais preditivos para o diagnóstico de puberdade precoce [PDF]

, 2002
OBJETIVO: A fim de distinguir o quadro de telarca precoce, benigno e auto-limitado, do início de um processo de puberdade precoce verdadeira estudamos, retrospectivamente, dois grupos de meninas com desenvolvimento mamário prematuro, buscando identificar
Damiani, Durval, Della Manna, Thais, Dichtchekenian, Vaê, Kuperman, Hilton, Setian, Nuvarte   +4 more
core   +3 more sources

GROWTH-HORMONE-RELEASING FACTOR IN GROWTH HORMONE DEFICIENCY: DEMONSTRATION OF A HYPOTHALAMIC DEFECT IN GROWTH HORMONE RELEASE

The Lancet, 1983
Four patients with hypothalamic tumours or idiopathic growth hormone (GH) deficiency, who were GH deficient by conventional criteria, responded to 200 micrograms synthetic hpGRF-40 with a clear rise in circulating GH.
A. Grossman, A. Grossman, J. A H Wass, J. A H Wass, G. M. Besser, G. M. Besser, David H. Coy, David H. Coy, N. Lytras, N. Lytras, M.O. Savage, M.O. Savage, J. Sueiras-Diaz, J. Sueiras-Diaz   +13 more
openaire   +3 more sources

Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist

Proceedings of the National Academy of Sciences of the United States of America, 2012
Islet transplantation is a feasible therapeutic alternative for metabolically labile patients with type 1 diabetes. The primary therapeutic target is stable glycemic control and prevention of complications associated with diabetes by reconstitution of ...
B. Ludwig, A. Rotem, Janine Schmid, G. Weir, C. Colton, M. Brendel, Tova Neufeld, N. Block, K. Yavriyants, A. Steffen, S. Ludwig, T. Chavakis, A. Reichel, Dimitri Azarov, B. Zimermann, S. Maimon, M. Balyura, Tania Rozenshtein, Noa Shabtay, P. Vardi, K. Bloch, P. de Vos, A. Schally, S. Bornstein, U. Barkai   +24 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Growth hormone secretagogues: history, mechanism of action, and clinical development

JCSM Rapid Communications, 2020
Growth hormone secretagogues (GHSs) are a generic term to describe compounds that increase growth hormone (GH) release. GHSs include agonists of the growth hormone secretagogue receptor (GHS‐R), whose natural ligand is ghrelin, and agonists of the growth
Junichi Ishida, Masakazu Saitoh, Nicole Ebner, Jochen Springer, Stefan D. Anker, Stephan vonHaehling   +5 more
doaj   +1 more source

Clinical and Laboratory Parameters of Gonadotropin-Releasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty [PDF]

Clinics, 2019
OBJECTIVE: There are no doubts about the clinical benefits of treatment with GnRH analogs for patients diagnosed with central precocious puberty (CPP). However, laboratory monitoring of CPP is still a matter of considerable controversy in the literature.
Lívia Grimaldi Abud Fujita, Heloísa Marcelina da Cunha Palhares, Adriana Paula da Silva, Janaíne Machado Tomé, Maria de Fátima Borges   +4 more
doaj   +2 more sources

Predicting environment effects on breast cancer by implementing machine learning [PDF]

arXiv, 2023
The biggest Breast cancer is increasingly a major factor in female fatalities, overtaking heart disease. While genetic factors are important in the growth of breast cancer, new research indicates that environmental factors also play a substantial role in its occurrence and progression. The literature on the various environmental factors that may affect
arxiv