Results 241 to 250 of about 509,115 (292)

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study. [PDF]

BMC Pediatr
Jo HY, Jang HJ, Cheon CK, Yoon JY, Yoo S, Lee JH, Lee JE, Kim YJ, Kim S, Kim HJ, Choi IJ, Kwak MJ.   +11 more
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Novel perspectives on growth hormone regulation of ovarian function: mechanisms, formulations, and therapeutic applications. [PDF]

Front Endocrinol (Lausanne)
Yang S, Luo W, Sun Y, Wang S.
europepmc   +1 more source

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source

Diastolic Dysfunction with Normal Ejection Fraction and Reduced Heart Rate in Mice Expressing Human Growth Hormone and Displaying Signs of Growth Hormone Insufficiency. [PDF]

Int J Mol Sci
Jin Y, Xiang B, Dolinsky VW, Kardami E, Cattini PA.   +4 more
europepmc   +1 more source

Relationship between comb development, immune regulation, growth hormone, testosterone, and growth traits in Tianfu broilers. [PDF]

Poult Sci
Qi K, Amevor FK, Liu Z, He J, Xu D, Zhai C, Wang Y, Wu L, Wang Y, Shu G, Zhao X.   +10 more
europepmc   +1 more source

Efficacy and Safety of Growth Hormone (GH) Therapy in Patients with SHOX Gene Variants. [PDF]

Children (Basel)
Sodero G, Arzilli F, Malavolta E, Lezzi M, Comes F, Villirillo A, Rigante D, Cipolla C.   +7 more
europepmc   +1 more source

Priming Short Children with Sex Steroids prior to Growth Hormone Testing Decreases the Frequency of Divergent Results.

Horm Res Paediatr
Lennartsson O, Nilsson O, Lodefalk M.
europepmc   +1 more source

Growth hormone-releasing hormone receptor (GHRH-R) and its signaling. [PDF]

Rev Endocr Metab Disord
Halmos G, Szabo Z, Dobos N, Juhasz E, Schally AV.   +4 more
europepmc   +1 more source