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Growth hormone therapy

The Indian Journal of Pediatrics, 2005
Growth hormone (GH) therapy has revolutionized treatment of children with growth hormone deficiency (GHD). Improved height outcome with final height in the target height range has been achieved in these children. Identification of Creutzfeldt-Jakob disease, a deadly prion mediated disorder, in recipients of pituitary GH accelerated the transition from ...
Anurag, Bajpai, P Sn, Menon
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Growth hormone abuse

Best Practice & Research Clinical Endocrinology & Metabolism, 2000
Doping with growth hormone (GH) has become an increasing problem in sports during the last 10 years. GH has a reputation of being fairly effective among GH users, although the effectiveness is not undisputed, and the few controlled studies that have been performed with supraphysiological GH doses to athletes have shown no significant positive effects ...
C, Ehrnborg, B A, Bengtsson, T, Rosén
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Growth Hormone Releasing Hormone Receptor

Receptors and Channels, 2002
Growth hormone releasing hormone receptor (GHRH-R) is a class II G protein-coupled receptor required for normal growth hormone (GH) synthesis and release from the pituitary, and for the normal growth and proliferation of somatotrophs within the pituitary.
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Growth hormone receptors

Life Sciences, 1988
The receptor for rabbit liver growth hormone (GH) has recently been purified and cloned. Sequencing data demonstrates that this site represents a new class of transmembrane receptor proteins containing covalently linked ubiquitin and N-linked oligosaccharides. Homology with the human GH liver receptor is estimated to be 84%.
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Growth hormone isoforms

Growth Hormone & IGF Research, 2009
Human growth hormone (GH) is a heterogeneous protein hormone consisting of several isoforms. The sources of this heterogeneity reside at the level of the genome, mRNA splicing, post-translational modification and metabolism. The GH gene cluster on chromosome 17q contains 2 GH genes (GH1 or GH-N and GH2 or GH-V) in addition to 2(-3) genes encoding the ...
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Placental Growth Hormones

Endocrine, 2002
Survival and development of the mammalian conceptus depends on a variety of factors. Fetal growth is controlled by genetic and environmental determinants that may limit the mother's capacity to provide an appropriate environment (e.g., space, nutrients, temperature). Exchanges between the mother and fetus take place within the placenta.
Marie-Christine, Lacroix   +4 more
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Extrapituitary growth hormone

Endocrine, 2010
Pituitary somatotrophs secrete growth hormone (GH) into the bloodstream, to act as a hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating GH are abolished after pituitary ablation or hypophysectomy, indicating its pituitary source.
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Growth hormone therapy

Best Practice & Research Clinical Endocrinology & Metabolism, 2002
Since 1958 growth hormone (GH) has been used as substitution treatment for children with GH deficiency. At present, it is clear that a dose of 0.23 mg/kg/week can lead to a final height close to target height, but in view of the wide inter-individual variation, alternative regimens based on invidualizing the dosage with the help of prediction models ...
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Human Growth Hormone

Nature, 1972
Human growth hormone is a successful treatment for children who without it would grow up to be midgets. This article describes present knowledge of its physiology, its role in the regulation of growth and its effect in treatment.
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Growth Hormone

Annual Review of Physiology, 1964
E, KNOBIL, J, HOTCHKISS
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