Results 121 to 130 of about 1,817,169 (352)
Aberrant Growth Plate Development in VDR/RXRγ Double Null Mutant Mice [PDF]
, 2001 Naoko Yagishita +10 more
openalex +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
An analytical and experimental study of crack extension in center-notched composites [PDF]
The normal stress ratio theory for crack extension in anisotropic materials is studied analytically and experimentally. The theory is applied within a microscopic-level analysis of a single center notch of arbitrary orientation in a unidirectional ...
Beuth, Jack L., Jr., Herakovich, Carl T.
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Bone & Joint ResearchAims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. Similarly, it is well established that low levels of sclerostin lead to enhanced bone formation
María Encarnacion Rodríguez-Ortiz +12 more
doaj +1 more source
Secondary three-dimensional instability in compressible boundary layers [PDF]
Three dimensional linear secondary instability theory is extended for compressible boundary layers on a flat plate in the presence of finite amplitude Tollmien-Schlichting waves.
El-Hady, Nabil M.
core +1 more source
Entrainment by axisymmetric jets impinging on a flat plate [PDF]
, 1966 An experimental technique is described for the determination of the entrainment in an axisymmetric gaseous jet impinging normally on a flat plate situated below the nozzle.
Nobbs, K. W., Searle, N.
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The kinetics of ice-lens growth in porous media [PDF]
, 2011 We analyse the growth rate of segregated ice (ice lenses) in freezing porous media. For typical colloidal materials such as soils we show that the commonly-employed Clapeyron equation is not valid macroscopically at the interface between the ice lens and
Peppin, S. S. L., Style, R. W.
core +1 more source