Results 131 to 140 of about 2,687 (162)

Role of the GRP/GRPR System in Regulating Brain Functions

ACS Chemical Neuroscience, 2023
Re-examining the relationship between neuropeptide systems and neural circuits will help us to understand more intensively the critical role of neuropeptides in brain function as the neural circuits responsible for specific brain functions are gradually revealed.
Tiantian Zhao, Aiwen Chen, Danqing Dai, Zhen Li, Xiao-Fei Gao, Lize Xiong   +5 more
openaire   +2 more sources

Oligoproline-based ligands for GRPR

2021
Data for "Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone"
openaire   +1 more source

GRPR Expression in Metastatic Cancers: A Review of Potential Application of GRPR-Radioligand Therapy

Seminars in Nuclear Medicine
Gastrin-Releasing Peptide Receptor (GRPR) represents a promising molecular target for radionuclide therapy (TRT) across a variety of malignancies due to its overexpression in several tumor types, including prostate, breast, lung, melanoma, cervix, neuroblastoma, head and neck, and colon cancers.
Aurélien Callaud, Heying Duan, Elif Hindié, Clément Morgat, Andrei Iagaru   +4 more
openaire   +2 more sources

BDNF and PDE4, but not the GRPR, Regulate Viability of Human Medulloblastoma Cells

Journal of Molecular Neuroscience, 2009
Medulloblastoma is the most common brain tumor of childhood. Emerging molecular targets in medulloblastoma include neurotrophin and neuropeptide receptors. In the present study, we have examined the influence of brain-derived neurotrophic factor (BDNF)/TrkB receptor- and gastrin-releasing peptide receptor (GRPR)-mediated signaling on the viability of ...
Anna Laura, Schmidt, Caroline Brunetto, de Farias, Ana Lucia, Abujamra, Flávio, Kapczinski, Gilberto, Schwartsmann, Algemir Lunardi, Brunetto, Rafael, Roesler   +6 more
openaire   +2 more sources

Targeting GRPR in urological cancers—from basic research to clinical application

Nature Reviews Urology, 2013
Gastrin releasing peptide (GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs. GRPR is overexpressed in neoplastic cells of most prostate cancers and some renal cell cancers and in the tumoral vessels of urinary tract cancers.
Mansi, Rosalba, Fleischmann, Achim, Mäcke, Helmut R., Reubi, Jean Claude   +3 more
openaire   +4 more sources

425 GRPR is an effective target for melanoma

Journal of Investigative Dermatology, 2022
J. Raymond, M. Pouteaux, V. Petit, Z. Aktary, L. Larue, V. Delmas   +5 more
openaire   +1 more source

Genetic and pharmacological inhibition of GRPR protects against acute kidney injury via attenuating renal inflammation and necroptosis

Molecular Therapy, 2023
Xiao-Ming Meng, Hui Y Lan, Shuai Shuai Xie   +2 more
exaly  

ESDR425 - GRPR is an effective target for melanoma

2022
Veronique Delmas, Lionel Larue, Zackie Aktary, Valérie Petit, Marie Pouteaux, Jérémy Raymond   +5 more
openaire   +1 more source

Bioorthogonal chemistry approach for theranostics of GRPR-expressing cancers

Nuclear Medicine and Biology, 2022
Lurdes Gano, Alice D’Onofrio, Francisco Silva, Paula Raposinho, Arkadiusz Sikora, Monika Orzełowska, Renata Mikołajczak, Piotr Garnuszek, António Paulo   +8 more
openaire   +1 more source

RADIOLABELED COMPOUNDS FOR IN VIVO IMAGING OF GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR) AND TREATMENT OF GRPR-RELATED DISORDERS

2023
ZHANG CHENGCHENG, LIN KUO-SHYAN, BÉNARD FRANÇOIS, WANG LEI, ZHANG ZHENGXING, BRATANOVIC IVICA   +5 more
openaire   +3 more sources