Results 1 to 10 of about 6,196 (153)

Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours [PDF]

ESMO Gastrointestinal Oncology
Background: There are limited treatment options for patients with advanced or metastatic gastrointestinal stromal tumours (GISTs) that lack mutations targetable by tyrosine kinase inhibitors (TKIs) or that have developed resistance to TKIs.
M. Berndsen, F. Puls, A. Thornell, Y. Arvidsson, A. Muth, S. Lindskog, E. Elias   +6 more
doaj   +4 more sources

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor. [PDF]

Int J Mol Sci, 2023
Advances in nanomedicine bring the attention of researchers to the molecular targets which can play a major role in the development of novel therapeutic and diagnostic modalities for cancer management. The choice of a proper molecular target can decide on the efficacy of the treatment and endorse the personalized medicine approach.
Rurarz BP, Bukowczyk M, Gibka N, Piastowska-Ciesielska AW, Karczmarczyk U, Ulański P.   +5 more
europepmc   +3 more sources

Human gastrin- releasing peptide receptor expression in women with uterine cervix cancer [PDF]

Frontiers in Oncology, 2023
Introduction212Pb-DOTAM-GRPR1 is a pharmaceutical radioimmunoconjugate consisiting of an α-particle-emitting radionuclide lead-212 (212Pb), a metal chelator DOTAM (1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane), and a gastrin ...
Charles A. Kunos, Denise Fabian, Dana Napier, Mark S. Stonecypher, Ravyn M. Duncan, Jason Hurt   +5 more
doaj   +2 more sources

Photoacoustic signal enhancement in dual-contrast gastrin-releasing peptide receptor-targeted nanobubbles [PDF]

Frontiers in Bioengineering and Biotechnology, 2023
Translatable imaging agents are a crucial element of successful molecular imaging. Photoacoustic molecular imaging relies on optical absorbing materials to generate a sufficient signal.
Shensheng Zhao, Shensheng Zhao, Leanne Lee, Leanne Lee, Yang Zhao, Yang Zhao, Yang Zhao, Nu-Chu Liang, Yun-Sheng Chen, Yun-Sheng Chen, Yun-Sheng Chen, Yun-Sheng Chen   +11 more
doaj   +2 more sources

Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics [PDF]

Biomolecules, 2023
Radiolabeled gastrin-releasing peptide receptor (GRPR) antagonists have shown great promise for the theranostics of prostate cancer; however, their suboptimal metabolic stability leaves room for improvements. It was recently shown that the replacement of
Ayman Abouzayed, Panagiotis Kanellopoulos, Alisa Gorislav, Vladimir Tolmachev, Theodosia Maina, Berthold A. Nock, Anna Orlova   +6 more
doaj   +2 more sources

The gastrin-releasing peptide receptor as a potential biomarker for squamous cell carcinoma [PDF]

Scientific Reports
The gastrin-releasing peptide receptor (GRPR) is expressed across multiple human cancer types, including head and neck tumors, and has also been detected in the oral mucosa of patients bearing head and neck neoplasms.
Danielly Brufatto Olguins, Júlia Caroline Marcolin, Mariane da Cunha Jaeger, Manoela Domingues Martins, Luis Fernando da Rosa Rivero, Gilberto Schwartsmann, Rafael Roesler, Marcelo Gerardin Poirot Land, Martina Lichtenfels, Caroline Brunetto de Farias   +9 more
doaj   +2 more sources

Preclinical assessment of IRDye800CW‐labeled gastrin‐releasing peptide receptor‐targeting peptide for near infrared‐II imaging of brain malignancies [PDF]

Bioengineering & Translational Medicine, 2023
We aimed to develop a new biocompatible gastrin‐releasing peptide receptor (GRPR) targeted optical probe, IRDye800‐RM26, for fluorescence image‐guided surgery (FGS) of brain malignancies in near‐infrared window II (NIR‐II) imaging.
Yuan Zhang, Li Wang, Chengkai Zhang, Jingjing Zhang, Linhao Yuan, Shucheng Jin, Wenjianlong Zhou, Xiudong Guan, Peng Kang, Chuanbao Zhang, Jie Tian, Xiaoyuan Chen, Deling Li, Wang Jia   +13 more
doaj   +2 more sources

Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography [PDF]

EJNMMI Radiopharmacy and Chemistry
Background The gastrin-releasing peptide receptor (GRPR) is overexpressed in the majority of primary prostate cancer lesions, with persistent expression in lymph nodes and bone metastases, making it a legitimate molecular target for diagnostic imaging ...
Panagiotis Kanellopoulos, Fanny Lundmark, Ayman Abouzayed, Lorenzo Jacopo Ilic Balestri, Esther Olaniran Håkansson, Karim Obeid, Luke R. Odell, Vladimir Tolmachev, Ulrika Rosenström, Jonas Eriksson, Anna Orlova   +10 more
doaj   +2 more sources

Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist [PDF]

EJNMMI Radiopharmacy and Chemistry, 2020
Background Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast.
Michael Hofstetter, Euy Sung Moon, Fabio D’Angelo, Lucien Geissbühler, Ian Alberts, Ali Afshar-Oromieh, Frank Rösch, Axel Rominger, Eleni Gourni   +8 more
doaj   +2 more sources

Stability Evaluation and Stabilization of a Gastrin-Releasing Peptide Receptor (GRPR) Targeting Imaging Pharmaceutical [PDF]

Molecules, 2019
The prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are identified as important targets on prostate cancer. Receptor-targeting radiolabeled imaging pharmaceuticals with high affinity and specificity are useful in ...
Arijit Ghosh, Karen Woolum, Shankaran Kothandaraman, Michael F. Tweedle, Krishan Kumar   +4 more
doaj   +2 more sources