Results 21 to 30 of about 1,763,342 (188)

Engineered antibody and neuropeptide mediated radionuclide targeting in prostate cancer [PDF]

, 2010
PhDProstate cancer (PC) is the most common cancer type in men in the western world and to date no definitive stratergy to image PC is avaliable. This thesis explores the possibility of using Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing
Kashani, Roxana M. G.
core   +4 more sources

Imaging the Distribution of Gastrin-Releasing Peptide Receptors in Cancer [PDF]

Journal of Nuclear Medicine, 2020
Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic, or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncologic applications. Such approaches have increased significantly over the past decade.
Baratto, Lucia, Duan, Heying, Mäcke, Helmut, Iagaru, Andrei   +3 more
openaire   +3 more sources

Gastrin-Releasing Peptide Receptor Expression in Lung Cancer [PDF]

Archives of Pathology and Laboratory Medicine, 2014
Context. —Gastrin-releasing peptide receptors (GRPRs) activate mitogen-activated protein kinase signaling pathway primarily through epidermal growth factor receptor activation and are under investigation as a molecular target because they are overexpressed in several solid tumors.
Mattei, Jane, Achcar, Rosane R.D., Cano, Carlos C.H., Macedo, Bruno B.R., Meurer, Luise, Batlle, Brenda B.S., Groshong, Steve S.D., Kulczynski, Jane J.M., Roesler, Rafael, Dal Lago, Lissandra, Brunetto, Andre A.T., Schwartsmann, Gilberto   +11 more
openaire   +3 more sources

Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide

Jornal de Pediatria, 2016
Objective: To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder.
Michele Michelin Becker, Cleonice Bosa, Vera Lorentz Oliveira-Freitas, José Roberto Goldim, Lygia Ohlweiler, Rafael Roesler, Gilberto Schwartsmann, Rudimar dos Santos Riesgo   +7 more
doaj   +3 more sources

Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification

Cells, 2020
Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality.
Hyun-Joo Park, Yeon Kim, Mi-Kyoung Kim, Jae Joon Hwang, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae   +6 more
doaj   +1 more source

CCK‐1 and CCK‐2 receptor agonism do not stimulate GLP‐1 and neurotensin secretion in the isolated perfused rat small intestine or GLP‐1 and PYY secretion in the rat colon

Physiological Reports, 2020
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig, Charlotte B. Christiansen, Jens F. Rehfeld, Jens J. Holst, Simon Veedfald   +4 more
doaj   +1 more source

Copper-67-Labeled Bombesin Peptide for Targeted Radionuclide Therapy of Prostate Cancer

Pharmaceuticals, 2022
The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging and therapy of prostate cancer using bombesin peptides that bind to the receptor with high affinity. Targeted copper theranostics (TCTs) using copper radionuclides,
Truc T. Huynh, Ellen M. van Dam, Sreeja Sreekumar, Cedric Mpoy, Benjamin J. Blyth, Fenella Muntz, Matthew J. Harris, Buck E. Rogers   +7 more
doaj   +1 more source

Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue [PDF]

ACS Omega, 2019
Joseph Lau, Etienne Rousseau, Zhengxing Zhang, Carlos F. Uribe, Hsiou-Ting Kuo, Jutta Zeisler, Chengcheng Zhang, Daniel Kwon, Kuo-Shyan Lin, François Bénard   +9 more
doaj   +2 more sources

ProGRP as early predictive marker of non–small-cell lung cancer to small-cell lung cancer transformation after EGFR-TKI treatment

Respiratory Medicine Case Reports, 2019
We report a case of non–small-cell lung cancer (NSCLC) to small-cell lung cancer (SCLC) transformation after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment.
Yasuhiro Kato, Yosuke Tanaka, Mitsunori Hino, Akihiko Gemma   +3 more
doaj   +1 more source

Regulation of gastric function by endogenous gastrin releasing peptide in humans: studies with a specific gastrin releasing peptide receptor antagonist [PDF]

Gut, 2001
BACKGROUND AND AIMS The main goal of our study was to characterise the activity of BIM26226 as a peripheral gastrin releasing peptide (GRP) receptor antagonist in healthy human subjects and to determine if endogenous GRP is a physiological regulator of gastric acid secretion and gastrin release.
P, Hildebrand, F S, Lehmann, S, Ketterer, A D, Christ, T, Stingelin, J, Beltinger, A H, Gibbons, D H, Coy, J, Calam, F, Larsen, C, Beglinger   +10 more
openaire   +2 more sources