Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification
Cells, 2020 Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality.
Hyun-Joo Park +6 more
doaj +3 more sources
Investigation of bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor [PDF]
Bioorganic & Medicinal Chemistry, 2016 Gastrin releasing peptide (GRP) receptor (GRPR), a bombesin family receptor, is overexpressed in many cancers including breast, prostate, pancreatic and lung. The targeting of therapeutics to GRPR can be achieved using the full-length (14 amino acid) GRP analogue Bombesin (BBN) or the truncated BBN(6-14) sequence, both of which bind GRPR with high ...
Begum, Anjuman Ara +2 more
openaire +6 more sources
Tumor Biology, 2017 Nerve fibers and neurotransmitters have increasingly been shown to have a role in tumor progression. Gastrin-releasing peptide is a neuropeptide linked to tumor aggressiveness, acting as an autocrine tumor growth factor by binding to its receptor ...
Natália Jaeger +4 more
doaj +2 more sources
Gastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma [PDF]
Scientific Reports, 2020 Oral squamous cell carcinoma (OSCC) is the most common malignant tumor that occurs in the oral mucosa. Pathological biopsy is still the current gold standard for OSCC diagnosis; however, some drawbacks need to be overcome.
Ran Li +7 more
doaj +2 more sources
Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective: This study aimed to verify the relation between gastrin-releasing peptide receptor (GRPR), oncogenic Human Papillomavirus (HPV) and cervical lesions severity.
Martina Lichtenfels +12 more
doaj +2 more sources
Gastrin-releasing peptide receptor (GRPR) as a novel biomarker and therapeutic target in prostate cancer [PDF]
Annals of MedicineAim: This comprehensive review aims to explore the potential applications of Gastrin-releasing peptide receptor (GRPR) in the diagnosis and treatment of prostate cancer.
Honghu Zhang +3 more
doaj +2 more sources
Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy
Annals of Oncology, 2007 Over the last two decades, several lines of experimental evidence have suggested that the gastrin-releasing peptide (GRP) may act as a growth factor in many types of cancer. For that reason, gastrin-releasing peptide receptor (GRPR) antagonists have been developed as anticancer candidate compounds, exhibiting impressive antitumoral activity both in ...
D B, Cornelio +2 more
openaire +4 more sources
Gastrin-releasing peptide receptor content in human glioma and normal brain
Brain Research Bulletin, 2010 The gastrin-releasing peptide receptor (GRPR) has been put forward as a therapeutic target in brain tumors. Here we evaluated GRPR presence in glioma specimens from patients as well as in normal human brain samples. Sections of paraffin-embedded brain tumors and non-neoplastic control brain tissue were analyzed with immunohistochemistry for GRPR ...
Debora Gazzana, Flores +7 more
openaire +4 more sources
Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide-Drug Conjugates. [PDF]
Int J Mol Sci, 2023 Gomena J +9 more
europepmc +2 more sources
Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons. [PDF]
Proc Natl Acad Sci U S A, 2021 Takanami K +6 more
europepmc +2 more sources