GRPR (Gastrin-Releasing Peptide Receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Bombesin (BB) and gastrin-releasing peptide (GRP) bind with high affinity to the GRP-receptor (GRP-R) which regulates release of gastrointestinal hormones, smooth muscle contraction and proliferation of epithelial as well as cancer cells. The GRP-R is a G-protein coupled receptor (GPCR) which activates phospholipase C signaling pathways.
Moody, TW
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Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours [PDF]
Journal of Clinical Pathology, 2004 Aims: To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours. Methods: Twenty six carcinoid tumours from the stomach, small intestine, appendix, and
Scott, N. +4 more
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Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils [PDF]
Proceedings of the National Academy of Sciences, 2011 Neutrophil migration to inflamed sites is crucial for both the initiation of inflammation and resolution of infection, yet these cells are involved in perpetuation of different chronic inflammatory diseases. Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors (GPCRs) involved in signal transmission in both ...
Rafael Sanguinetti, Czepielewski +8 more
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Stability Evaluation and Stabilization of a Gastrin-Releasing Peptide Receptor (GRPR) Targeting Imaging Pharmaceutical [PDF]
Molecules, 2019 The prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are identified as important targets on prostate cancer. Receptor-targeting radiolabeled imaging pharmaceuticals with high affinity and specificity are useful in ...
Arijit Ghosh +4 more
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Gastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma [PDF]
Scientific Reports, 2020 Oral squamous cell carcinoma (OSCC) is the most common malignant tumor that occurs in the oral mucosa. Pathological biopsy is still the current gold standard for OSCC diagnosis; however, some drawbacks need to be overcome.
Ran Li +7 more
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Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective: This study aimed to verify the relation between gastrin-releasing peptide receptor (GRPR), oncogenic Human Papillomavirus (HPV) and cervical lesions severity.
Martina Lichtenfels +12 more
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International Journal of Nanomedicine, 2017 Danting Cui,1 Xiaodan Lu,1 Chenggong Yan,1 Xiang Liu,1 Meirong Hou,1 Qi Xia,2 Yikai Xu,1 Ruiyuan Liu2,3 1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2School of ...
Cui DT +7 more
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Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor. [PDF]
Int J Mol Sci, 2023 Advances in nanomedicine bring the attention of researchers to the molecular targets which can play a major role in the development of novel therapeutic and diagnostic modalities for cancer management. The choice of a proper molecular target can decide on the efficacy of the treatment and endorse the personalized medicine approach.
Rurarz BP +5 more
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Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates [PDF]
International Journal of Molecular Sciences, 2023 Beáta Biri-Kovács +2 more
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Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. [PDF]
, 1992 Helicobacter pylori increases gastrin release in duodenal ulcer patients. This may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells.
Ghosh, P +6 more
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