Results 41 to 50 of about 1,763,342 (188)

Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice

Cell Reports, 2018
Summary: Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive.
Admire Munanairi, Xian-Yu Liu, Devin M. Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R. Bruchas, Zhou-Feng Chen   +20 more
doaj   +1 more source

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

Pharmaceutics, 2020
The targeting of gastrin-releasing peptide receptors (GRPR) was recently proposed for targeted therapy, e.g., radiotherapy. Multiple and frequent injections of peptide-based therapeutic agents would be required due to rapid blood clearance.
Ayman Abouzayed, Hanna Tano, Ábel Nagy, Sara S. Rinne, Fadya Wadeea, Sharmishtaa Kumar, Kristina Westerlund, Vladimir Tolmachev, Amelie Eriksson Karlström, Anna Orlova   +9 more
doaj   +1 more source

CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach [PDF]

, 2008
We retrospectively studied the single and combined diagnostic value of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP), which were routinely analysed in ...
Gruber, Christine, Hatz, Rudolf, Reinmiedl, Judith, Stieber, Petra, Nagel, Dorothea   +4 more
core   +1 more source

Gastrin-Releasing Peptide Receptor Mediates Activation of the Epidermal Growth Factor Receptor in Lung Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2005
Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung carcinoma (NSCLC).
Sufi Mary Thomas, Jennifer Rubin Grandis, Abbey L. Wentzel, William E. Gooding, Vivian Wai Yan Lui, Jill M. Siegfried   +5 more
doaj   +1 more source

Radionuclide GRPR imaging in malignant pathology of the mammary and prostate glands: clinical experience

Бюллетень сибирской медицины
In this lecture, we presented current clinical studies on targeted radionuclide imaging of breast and prostate tumors with overexpression of the gastrin-releasing peptide receptor (GRPR). The gastrin-releasing peptide receptor is a transmembrane receptor,
O. D. Bragina, A. G. Ivanova, E. A. Usynin   +2 more
doaj   +1 more source

Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]

, 1994
The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Strasburger, Christian J., Renner, U., Müller, O., Stalla, G., Brockmeier, S., Schopohl, Jochen, Strasburger, C., Müller, Otto-Albrecht, Schopohl, J., Strasburger, C. J., Werder, K., Lange, M., Werder, K. von, Stalla, G. K., Müller, O. A.   +14 more
core   +1 more source

Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis

Cells, 2020
Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim   +6 more
doaj   +1 more source

Diagnostic role of gastrin-releasing peptide receptors in oncology

Radiation Diagnostics, Radiation Therapy, 2021
Tumor receptor-targeted diagnostic imaging is an area of research that identifies a biomarker that is overexpressed on the surface of cancer cells and binds its ligand to carriers, allowing imaging of the tumor process. The success of this approach depends on the selectivity of the receptor for certain malignant cells, as well as on its ability to ...
P. Korol, O. Shcherbina
openaire   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Phosphorylation Uncouples the Gastrin-releasing Peptide Receptor from Gq [PDF]

Journal of Biological Chemistry, 1999
Previous work on the desensitization of G protein-coupled receptors has focused on the role of arrestin binding following receptor phosphorylation. We have examined the hypothesis that phosphorylation alone contributes to desensitization. In this study we demonstrate that for the G(q)-coupled gastrin-releasing peptide receptor (GRP-R), phosphorylation ...
G S, Kroog, X, Jian, L, Chen, J K, Northup, J F, Battey   +4 more
openaire   +2 more sources