Results 41 to 50 of about 6,216 (159)

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils [PDF]

Proceedings of the National Academy of Sciences, 2011
Neutrophil migration to inflamed sites is crucial for both the initiation of inflammation and resolution of infection, yet these cells are involved in perpetuation of different chronic inflammatory diseases. Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors (GPCRs) involved in signal transmission in both ...
Rafael Sanguinetti, Czepielewski, Bárbara Nery, Porto, Lucas Bortolotto, Rizzo, Rafael, Roesler, Ana Lúcia, Abujamra, Larissa Garcia, Pinto, Gilberto, Schwartsmann, Fernando de Queiroz, Cunha, Cristina, Bonorino   +8 more
openaire   +2 more sources

Gastrin-Releasing Peptide Receptor Mediates Activation of the Epidermal Growth Factor Receptor in Lung Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2005
Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung carcinoma (NSCLC).
Sufi Mary Thomas, Jennifer Rubin Grandis, Abbey L. Wentzel, William E. Gooding, Vivian Wai Yan Lui, Jill M. Siegfried   +5 more
doaj   +1 more source

Radionuclide GRPR imaging in malignant pathology of the mammary and prostate glands: clinical experience

Бюллетень сибирской медицины
In this lecture, we presented current clinical studies on targeted radionuclide imaging of breast and prostate tumors with overexpression of the gastrin-releasing peptide receptor (GRPR). The gastrin-releasing peptide receptor is a transmembrane receptor,
O. D. Bragina, A. G. Ivanova, E. A. Usynin   +2 more
doaj   +1 more source

Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis

Cells, 2020
Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim   +6 more
doaj   +1 more source

Diagnostic role of gastrin-releasing peptide receptors in oncology

Radiation Diagnostics, Radiation Therapy, 2021
Tumor receptor-targeted diagnostic imaging is an area of research that identifies a biomarker that is overexpressed on the surface of cancer cells and binds its ligand to carriers, allowing imaging of the tumor process. The success of this approach depends on the selectivity of the receptor for certain malignant cells, as well as on its ability to ...
P. Korol, O. Shcherbina
openaire   +2 more sources

Phosphorylation Uncouples the Gastrin-releasing Peptide Receptor from Gq [PDF]

Journal of Biological Chemistry, 1999
Previous work on the desensitization of G protein-coupled receptors has focused on the role of arrestin binding following receptor phosphorylation. We have examined the hypothesis that phosphorylation alone contributes to desensitization. In this study we demonstrate that for the G(q)-coupled gastrin-releasing peptide receptor (GRP-R), phosphorylation ...
G S, Kroog, X, Jian, L, Chen, J K, Northup, J F, Battey   +4 more
openaire   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Prostate Cancer Theranostics Targeting Gastrin-Releasing Peptide Receptors

Molecular Imaging and Biology, 2017
Gastrin-releasing peptide receptors (GRPRs), part of the bombesin (BBN) family, are aberrantly overexpressed in many cancers, including those of the breast, prostate, pancreas, and lung, and therefore present an attractive target for cancer diagnosis and therapy. Different bombesin analogs have been radiolabeled and used for imaging diagnosis, staging,
Lucia Baratto, Hossein Jadvar, Andrei Iagaru   +2 more
openaire   +3 more sources

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Identification and Discrimination of Sulfated and Unsulfated Gut‐Hormone Biomarkers in Human Serum by Nanopore

Small, EarlyView.
This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu, Laurent Bacri, Juan Pelta, Benjamin Cressiot   +3 more
wiley   +1 more source