Results 1 to 10 of about 5,537 (176)

Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus [PDF]

Pharmacology Research & Perspectives
Gastrin‐releasing peptide (GRP) and neuromedin B (NMB) are found in the stomach's myenteric plexus and muscular layers. When exogenously administered, they contract stomach muscle in several species, but their ability to modulate enteric nerve functions ...
Diego Currò, Raj Makwana, Gareth J. Sanger   +2 more
doaj   +3 more sources

Radiolabeled Bombesin Analogs [PDF]

Cancers, 2021
The gastrin-releasing peptide receptor (GRPR) is expressed in high numbers in a variety of human tumors, including the frequently occurring prostate and breast cancers, and therefore provides the rationale for directing diagnostic or therapeutic radionuclides on cancer lesions after administration of anti-GRPR peptide analogs.
Theodosia Maina, Berthold A Nock, Simone Dalm   +2 more
exaly   +4 more sources

Pathology of a Canine Model of Localized Prostate Carcinoma. [PDF]

Prostate
ABSTRACT Background Dogs spontaneously develop prostate carcinoma (PC) and share prostate gland anatomy, physiology, and size to men. Over the last 15 years, we have developed and refined a canine model of focal PC to evaluate therapeutic‐diagnostic (theranostic) interventions.
Hoggard NK, Berg FM, Szczepaniak MR, Wang X, Kantake N, Ramamurthy G, Gong L, Hostnik ET, Kumar K, Ghosh A, Luo D, Knopp MV, Keller JM, Keller ET, Exner AA, Basilion JP, Tweedle MF, Rosol TJ.   +17 more
europepmc   +2 more sources

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide [PDF]

Frontiers in Pharmacology
Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer therapeutics, mainly due to their cost-effective and chemically defined production and lower antigenicity compared to ADCs, among other ...
Dayma Llanes, Robert Rennert, Paul Jänicke, Ibrahim Morgan, Leslie Reguera, Leslie Reguera, Daniel G. Rivera, Daniel G. Rivera, Manuel G. Ricardo, Manuel G. Ricardo, Ludger A. Wessjohann   +10 more
doaj   +2 more sources

Linking GERD and the Peptide Bombesin: A New Therapeutic Strategy to Modulate Inflammatory, Oxidative Stress and Clinical Biochemistry Parameters [PDF]

Antioxidants
Gastroesophageal reflux disease (GERD) represents one of the most prevalent foregut illnesses, affecting a large portion of individuals worldwide. Recent research has shown that inflammatory mediators such as cytokines, chemokines, and enzymes are ...
Alessio Ardizzone, Sarah Adriana Scuderi, Lelio Crupi, Michela Campolo, Irene Paterniti, Anna Paola Capra, Emanuela Esposito   +6 more
doaj   +2 more sources

Prostate Cancer Imaging Beyond PSMA: Applications of GRPR, AR, and Amino Acid Tracers [PDF]

Diagnostics
Prostate-specific membrane antigen (PSMA) targeting agents have been the cornerstone of advanced prostate cancer (PCa) management in theranostics due to their high sensitivity for detecting and treating metastatic disease.
Farzana Z. Ali
doaj   +2 more sources

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies. [PDF]

Chemistry
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Yang M, Wang S.
europepmc   +2 more sources

Novel ¹⁷⁷Lu-Labeled [Thz¹⁴]Bombesin(6–14) Derivatives with Low Pancreas Accumulation for Targeting Gastrin-Releasing Peptide Receptor-Expressing Cancer [PDF]

Pharmaceuticals
Background/Objectives: Gastrin-releasing peptide receptor is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake of reported GRPR-targeted radioligands limits their clinical applications.
Lei Wang, Devon E. Chapple, Hsiou-Ting Kuo, Sara Kurkowska, Ryan P. Wilson, Wing Sum Lau, Pauline Ng, Carlos Uribe, François Bénard, Kuo-Shyan Lin   +9 more
doaj   +2 more sources

Gastrin-Releasing Peptide Receptors Stimulate MAPK-Mediated Growth of Lung Cancer Cells by Transactivating HER4 in a Neuregulin-1, MAP Kinase-Dependent Manner Requiring Activation of the ROS-System [PDF]

Biology
The bombesin (Bn) receptor family [Gastrin-releasing peptide (GRPR/BB2R) and Neuromedin B receptors (NMBR/BB1R)] are G-protein coupled receptors (GPCR’s) with potent growth effects on normal tissues/numerous cancers, often by transactivating the ErbB ...
Terry W. Moody, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen   +4 more
doaj   +2 more sources

Two novel bombesin-like neuropeptides from the skin secretion of Pelophylax kl. esculentus: Ex vivo pharmacological characterization on rat smooth muscle types

Frontiers in Molecular Biosciences, 2022
Mammalian bombesin-like neuropeptides (BLPs) play an important role in regulation of physiological and pathophysiological processes. Frog skin-derived BLPs, of smaller size and diverse lengths and sequences at their N-terminus, have attracted the ...
Luyao Zhang, Luyao Zhang, Chen Chen, Wanchen Zou, Xiaoling Chen, Mei Zhou, Chengbang Ma, Xinping Xi, Tianbao Chen, Chris Shaw, Mingchun Liu, Lei Wang   +11 more
doaj   +1 more source