Results 1 to 10 of about 5,994 (113)

Linking GERD and the Peptide Bombesin: A New Therapeutic Strategy to Modulate Inflammatory, Oxidative Stress and Clinical Biochemistry Parameters [PDF]

Antioxidants
Gastroesophageal reflux disease (GERD) represents one of the most prevalent foregut illnesses, affecting a large portion of individuals worldwide. Recent research has shown that inflammatory mediators such as cytokines, chemokines, and enzymes are ...
Alessio Ardizzone, Sarah Adriana Scuderi, Lelio Crupi, Michela Campolo, Irene Paterniti, Anna Paola Capra, Emanuela Esposito   +6 more
doaj   +2 more sources

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide [PDF]

Frontiers in Pharmacology
Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer therapeutics, mainly due to their cost-effective and chemically defined production and lower antigenicity compared to ADCs, among other ...
Dayma Llanes, Robert Rennert, Paul Jänicke, Ibrahim Morgan, Leslie Reguera, Leslie Reguera, Daniel G. Rivera, Daniel G. Rivera, Manuel G. Ricardo, Manuel G. Ricardo, Ludger A. Wessjohann   +10 more
doaj   +2 more sources

Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus [PDF]

Pharmacology Research & Perspectives
Gastrin‐releasing peptide (GRP) and neuromedin B (NMB) are found in the stomach's myenteric plexus and muscular layers. When exogenously administered, they contract stomach muscle in several species, but their ability to modulate enteric nerve functions ...
Diego Currò, Raj Makwana, Gareth J. Sanger   +2 more
doaj   +2 more sources

Prostate Cancer Imaging Beyond PSMA: Applications of GRPR, AR, and Amino Acid Tracers [PDF]

Diagnostics
Prostate-specific membrane antigen (PSMA) targeting agents have been the cornerstone of advanced prostate cancer (PCa) management in theranostics due to their high sensitivity for detecting and treating metastatic disease.
Farzana Z. Ali
doaj   +2 more sources

Novel ¹⁷⁷Lu-Labeled [Thz¹⁴]Bombesin(6–14) Derivatives with Low Pancreas Accumulation for Targeting Gastrin-Releasing Peptide Receptor-Expressing Cancer [PDF]

Pharmaceuticals
Background/Objectives: Gastrin-releasing peptide receptor is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake of reported GRPR-targeted radioligands limits their clinical applications.
Lei Wang, Devon E. Chapple, Hsiou-Ting Kuo, Sara Kurkowska, Ryan P. Wilson, Wing Sum Lau, Pauline Ng, Carlos Uribe, François Bénard, Kuo-Shyan Lin   +9 more
doaj   +2 more sources

Gastrin-Releasing Peptide Receptors Stimulate MAPK-Mediated Growth of Lung Cancer Cells by Transactivating HER4 in a Neuregulin-1, MAP Kinase-Dependent Manner Requiring Activation of the ROS-System [PDF]

Biology
The bombesin (Bn) receptor family [Gastrin-releasing peptide (GRPR/BB2R) and Neuromedin B receptors (NMBR/BB1R)] are G-protein coupled receptors (GPCR’s) with potent growth effects on normal tissues/numerous cancers, often by transactivating the ErbB ...
Terry W. Moody, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen   +4 more
doaj   +2 more sources

Two novel bombesin-like neuropeptides from the skin secretion of Pelophylax kl. esculentus: Ex vivo pharmacological characterization on rat smooth muscle types

Frontiers in Molecular Biosciences, 2022
Mammalian bombesin-like neuropeptides (BLPs) play an important role in regulation of physiological and pathophysiological processes. Frog skin-derived BLPs, of smaller size and diverse lengths and sequences at their N-terminus, have attracted the ...
Luyao Zhang, Luyao Zhang, Chen Chen, Wanchen Zou, Xiaoling Chen, Mei Zhou, Chengbang Ma, Xinping Xi, Tianbao Chen, Chris Shaw, Mingchun Liu, Lei Wang   +11 more
doaj   +1 more source

Preparation of 64Cu-NODAGA-RGD-BBN labeled compound and its absorbed dose estimation in humans based on mouse data [PDF]

مجله علوم و فنون هسته‌ای, 2023
Calculating the absorbed dose in the human body is one of the first steps in radiopharmaceutical development. This study estimates the dose absorbed by humans from the novel identified compound of 64Cu-NODAGA-RGD-BBN.
N. Amraee, B. Alirezapour, M. Hosntalab, A. Haddadi, H. Yousefnia   +4 more
doaj   +1 more source

The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus

Scientific Reports, 2021
Bombesin is a putative antibacterial peptide isolated from the skin of the frog, Bombina bombina. Two related (bombesin-like) peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been found in mammals.
Asuka Hirooka, Mayuko Hamada, Daiki Fujiyama, Keiko Takanami, Yasuhisa Kobayashi, Takumi Oti, Yukitoshi Katayama, Tatsuya Sakamoto, Hirotaka Sakamoto   +8 more
doaj   +1 more source

Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. [PDF]

PLoS ONE, 2013
Pruritus (itch) is a severe side effect associated with the use of drugs as well as hepatic and hematological disorders. Previous studies in rodents suggest that bombesin receptor subtypes i.e.
Devki D Sukhtankar, Mei-Chuan Ko
doaj   +1 more source