Results 11 to 20 of about 9,394 (210)

IV. Effects of bombesin on behavior [PDF]

Life Sciences, 1985
This report describes the influence of bombesin on the gross behavior of goldfish, frogs, mice, rats, guinea pigs, rabbits, chicks, pigeons and monkeys. Goldfish, frogs, chicks and pigeons were overtly unaffected by bombesin given centrally and/or peripherally. Mice, rats, guinea pigs, rabbits and monkeys responded quickly to intracerebroventricular (i.
Cowan, Alan, Khunawat, P., Zhu, X. Zu, Gmerek, Debra E.   +3 more
openaire   +5 more sources

Effects of Bombesin and Bombesin-Like Peptides on Gastrointestinal Myoelectric Activity

Gastroenterology, 1975
Gastrointestinal myoelectric activity was studied during intravenous infusion of bombesin and bombesin-like peptides in conscious dogs with electrodes chronically implanted at different levels between the stomach and the rectum. The peptides used were bombesin, the COOH-terminal hepta- octa-, and nonapeptide of bombesin, and litorin, a new natural ...
CAPRILLI R., MELCHIORRI P., IMPROTA G., VERNIA P., FRIERI, Giuseppe   +4 more
openaire   +5 more sources

[D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1987
Previous attempts to develop analogues of bombesin that function as specific receptor antagonists have been unsuccessful. Alteration of the histidine in luteinizing hormone releasing factor has resulted in analogues that function as competitive antagonists. In the present study we have used a similar strategy and altered the histidine in bombesin.
P, Heinz-Erian, D H, Coy, M, Tamura, S W, Jones, J D, Gardner, R T, Jensen   +5 more
openaire   +3 more sources

Radiolabeled Bombesin Analogs [PDF]

Cancers, 2021
The gastrin-releasing peptide receptor (GRPR) is expressed in high numbers in a variety of human tumors, including the frequently occurring prostate and breast cancers, and therefore provides the rationale for directing diagnostic or therapeutic radionuclides on cancer lesions after administration of anti-GRPR peptide analogs.
Rosalba Mansi, Berthold A. Nock, Simone U. Dalm, Martijn B. Busstra, Wytske M. van Weerden, Theodosia Maina   +5 more
openaire   +3 more sources

Pathology of a Canine Model of Localized Prostate Carcinoma. [PDF]

Prostate
ABSTRACT Background Dogs spontaneously develop prostate carcinoma (PC) and share prostate gland anatomy, physiology, and size to men. Over the last 15 years, we have developed and refined a canine model of focal PC to evaluate therapeutic‐diagnostic (theranostic) interventions.
Hoggard NK, Berg FM, Szczepaniak MR, Wang X, Kantake N, Ramamurthy G, Gong L, Hostnik ET, Kumar K, Ghosh A, Luo D, Knopp MV, Keller JM, Keller ET, Exner AA, Basilion JP, Tweedle MF, Rosol TJ.   +17 more
europepmc   +2 more sources

Bombesin-evoked gastrin release and calcium signaling in human antral G cells in culture

, 1999
Amplification of mRNA from a human antral cell culture preparation demonstrated the presence of two receptors of the bombesin and gastrin- releasing peptide family, GRPR-1 and BRS-3.
R. M. Meloche (17189728), Paul Squires (17167891), A. M. J. Buchan (17189611)   +2 more
core   +5 more sources

Bombesins: A New Frontier in Hybrid Compound Development

Pharmaceutics, 2023
Recently, bombesin (BN) and its analogs have attracted much attention as excellent anticancer agents because they interact with specific receptors widely distributed on the surface of various cancer cells. However, their biological properties proceed far
Pawel Serafin, Patrycja Kleczkowska
doaj   +1 more source

Bombesin Receptor Family Activation and CNS/Neural Tumors: Review of Evidence Supporting Possible Role for Novel Targeted Therapy

Frontiers in Endocrinology, 2021
G-protein-coupled receptors (GPCRs) are increasingly being considered as possible therapeutic targets in cancers. Activation of GPCR on tumors can have prominent growth effects, and GPCRs are frequently over-/ectopically expressed on tumors and thus can ...
Terry W. Moody, Lingaku Lee, Lingaku Lee, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen   +6 more
doaj   +1 more source

Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice [PDF]

Brazilian Journal of Medical and Biological Research, 2015
Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic ...
F.N. Carlesso, L.L. Fuscaldi, R.S. Araújo, C.S. Teixeira, M.C. Oliveira, S.O.A. Fernandes, G.D. Cassali, D.C. Reis, A.L.B. Barros, V.N. Cardoso   +9 more
doaj   +3 more sources

Preclinical Evaluation of NHS-Activated Gold Nanoparticles Functionalized with Bombesin or Neurotensin-Like Peptides for Targeting Colon and Prostate Tumours

Molecules, 2020
Recent advances and large-scale use of hybrid imaging modalities like PET-CT have led to the necessity of improving nano-drug carriers that can facilitate both functional and metabolic screening in nuclear medicine applications. In this study, we focused
Livia Elena Chilug, Dana Niculae, Radu Anton Leonte, Alexandrina Nan, Rodica Turcu, Cosmin Mustaciosu, Radu Marian Serban, Vasile Lavric, Gina Manda   +8 more
doaj   +1 more source