Results 11 to 20 of about 5,537 (176)
Preparation of 64Cu-NODAGA-RGD-BBN labeled compound and its absorbed dose estimation in humans based on mouse data [PDF]
مجله علوم و فنون هستهای, 2023 Calculating the absorbed dose in the human body is one of the first steps in radiopharmaceutical development. This study estimates the dose absorbed by humans from the novel identified compound of 64Cu-NODAGA-RGD-BBN.
N. Amraee +4 more
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Scientific Reports, 2021 Bombesin is a putative antibacterial peptide isolated from the skin of the frog, Bombina bombina. Two related (bombesin-like) peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been found in mammals.
Asuka Hirooka +8 more
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Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. [PDF]
PLoS ONE, 2013 Pruritus (itch) is a severe side effect associated with the use of drugs as well as hepatic and hematological disorders. Previous studies in rodents suggest that bombesin receptor subtypes i.e.
Devki D Sukhtankar, Mei-Chuan Ko
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Bombesins: A New Frontier in Hybrid Compound Development
Pharmaceutics, 2023 Recently, bombesin (BN) and its analogs have attracted much attention as excellent anticancer agents because they interact with specific receptors widely distributed on the surface of various cancer cells. However, their biological properties proceed far
Pawel Serafin, Patrycja Kleczkowska
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Frontiers in Endocrinology, 2021 G-protein-coupled receptors (GPCRs) are increasingly being considered as possible therapeutic targets in cancers. Activation of GPCR on tumors can have prominent growth effects, and GPCRs are frequently over-/ectopically expressed on tumors and thus can ...
Terry W. Moody +6 more
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Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice [PDF]
Brazilian Journal of Medical and Biological Research, 2015 Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic ...
F.N. Carlesso +9 more
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Molecules, 2020 Recent advances and large-scale use of hybrid imaging modalities like PET-CT have led to the necessity of improving nano-drug carriers that can facilitate both functional and metabolic screening in nuclear medicine applications. In this study, we focused
Livia Elena Chilug +8 more
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Molecules, 2017 Bombesin-like peptides, which were identified from a diversity of amphibian skin secretions, have been demonstrated to possess several biological functions such as stimulation of smooth muscle contraction and regulation of food intake.
Xiaowei Zhou +8 more
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Bombesin analogue-mediated delivery preferentially enhances the cytotoxicity of a mitochondria-disrupting peptide in tumor cells. [PDF]
PLoS ONE, 2013 Tumor-homing peptides that recognize specific markers on tumor cells have shown potential as drug carriers for targeted cancer therapy. Bombesin receptors are frequently overexpressed or ectopically expressed in a wide range of human tumors. Bombesin and
Hao Yang +6 more
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Physiological Reports, 2020 Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig +4 more
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