Results 41 to 50 of about 5,537 (176)

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source

Influence of radiotherapy dose rate on gold nanoparticle‐induced radiosensitization from high dose‐rate brachytherapy and external beam therapy

Medical Physics, Volume 53, Issue 3, March 2026.
Abstract Background Associated normal tissue toxicity from current radiotherapy (RT) treatments limits effective dose escalation in the tumor to achieve nominal treatment results. Gold nanoparticles (GNPs) as radiosensitizing agents to locally increase photoelectron production have gained interest as a safe and viable method to improve therapeutic ...
Daniel Cecchi, Nolan Jackson, Sacha Freeman, Kieren O'Neil, Mehran Goharian, Wayne Beckham, Devika B. Chithrani   +6 more
wiley   +1 more source

Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells. [PDF]

PLoS ONE, 2011
Bombesin receptor subtype 3 (BRS-3), the orphan bombesin receptor, may play a role in the regulation of stress responses in lung and airway epithelia.
Hui Jun Liu, Yu Rong Tan, Meng Lan Li, Chi Liu, Yang Xiang, Xiao Qun Qin   +5 more
doaj   +1 more source

⁶⁸Ga-Labeled [Leu¹³ψThz¹⁴]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake

Molecules, 2022
The gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled receptor that is overexpressed in many solid cancers and is a promising target for cancer imaging and therapy.
Lei Wang, Zhengxing Zhang, Helen Merkens, Jutta Zeisler, Chengcheng Zhang, Aron Roxin, Ruiyan Tan, François Bénard, Kuo-Shyan Lin   +8 more
doaj   +1 more source

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer

Biomedicines, 2018
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75).
Gail L. Matters, John F. Harms
doaj   +1 more source

Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2

Respiratory Research, 2023
Background Clinical and experimental evidence shows lung fluid volume as a modulator of fetal lung growth with important value in treating fetal lung hypoplasia.
Ana N. Gonçalves, Rute S. Moura, Jorge Correia-Pinto, Cristina Nogueira-Silva   +3 more
doaj   +1 more source

The DMHGABA Neurons Play a Crucial Role in the Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

Advanced Science, Volume 13, Issue 5, 27 January 2026.
GABAergic neurons in the dorsomedial hypothalamus (DMHGABA neurons) act as a key neuronal population controlling cold exposure‐induced white adipose tissue browning. DMHGABA neurons regulate the browning through DMH to the lateral preoptic area (LPO) projection.
Zhijie Su, Yujia Hou, Bingwei Wang, Qian Zhou, Wen Yang, Bingbing Guo, Chenyu Zhang, Miao Zhao, Xiaoning Yang, Jiarui Liu, Xiangyang Xie, Lihua Qin, Weiguang Zhang, Wei L. Shen, Ruimao Zheng   +14 more
wiley   +1 more source

The Chemistry of Subphthalocyanines: Synthetic Strategies for their Axial, Peripheral, and Remote Postfunctionalization

ChemistryEurope, Volume 4, Issue 1, January 2026.
From axial and peripheral reactivity to remote derivatization, the chemical versatility of subphthalocyanines (SubPcs) renders them ideal scaffolds for the design of advanced functional materials. This review assembles the synthetic toolbox, key reaction conditions, and future challenges in SubPc functionalization, guiding the development of next ...
Marta Gómez‐Gómez, Juan Laforga‐Martín, Jorge Labrador‐Santiago, Jorge Labella, Tomás Torres   +4 more
wiley   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source